可定制的人工模拟器，用于开发、规划和培训非人灵长类动物的神经生理学和外科手术人员。

IF 2.3 4区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Neuroscience Methods Pub Date : 2025-10-01 DOI:10.1016/j.jneumeth.2025.110587

Lydia I. Smith , Amy L. Orsborn

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引用次数: 0

摘要

背景：神经科学研究人员经常通过外科手术将硬件植入模式生物以测量和操纵神经活动。在非人类灵长类动物中设计和优化这些程序通常需要给动物注射镇静剂或实施安乐死。人工组织技术可以减少这一过程中动物的使用，但现有的模拟器不包括所有相关组织，也不便于迭代设计过程。新方法：我们为神经科学研究创造了一个全面的、可定制的、模块化的手术模拟器。我们的模拟器将人造头骨、大脑和软组织（皮肤和肌肉）整合到一个具有适应性组件的三维模型中。结果：结合三维软组织可以改善手术和植入物的设计，这可能有助于提高植入物的使用寿命、研究成果和动物福利。我们的模块化设计允许研究人员快速原型设计和交换部件，以反映整个研究中的植入物或解剖变化。整合所有相关组织也有助于外科实践，并改善与兽医的沟通。我们的方法是低成本的（几百美元），并使用现成的工具，如3D打印。我们还提供了不同的非人类灵长类物种的模型，以增加对我们方法的访问。与现有方法的比较：我们的方法改进了过去用于神经科学研究的手术模拟器：采用现有的皮肤和肌肉人工组织技术，更准确地表示颅骨三维几何形状，结合植入物设计相关的所有组织模型，并引入模块化设计，增加灵活性/定制性。结论：我们发现该手术模拟器是一种廉价的工具，可用于计划和实践外科手术，以及原型新的神经科学实验硬件。

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Customizable artificial simulator for developing, planning, and training personnel on neurophysiology and surgical procedures in non-human primates

Background

Neuroscience researchers often surgically implant hardware into model organisms to measure and manipulate neural activity. Designing and optimizing these procedures in non-human primates often requires sedated or euthanized animals. Artificial tissue technologies can reduce animal use in this process, but existing simulators do not include all relevant tissues and do not facilitate iterative design processes.

New method

We created a comprehensive, customizable, and modular surgical simulator for neuroscience research. Our simulator incorporates artificial skull, brain, and soft tissues (skin and muscle) into one 3-dimensional model with adaptable components.

Results

Incorporating 3-dimensional soft tissues enabled surgical and implant design improvements, which may contribute to improving implant longevity, research outcomes, and animal wellbeing. Our modular design allowed researchers to rapidly prototype designs and exchange parts to reflect implant or anatomical changes across a study. Incorporating all relevant tissues also enabled surgical practice and improved communication with veterinarians. Our approach is low-cost (a few hundred dollars) and uses readily available tools like 3D printing. We also provide models of different non-human primate species to increase access to our approach.

Comparison with existing methods

Our method improves upon past surgical simulators for neuroscience research by: adapting existing skin and muscle artificial tissue technologies to more accurately represent cranial 3-dimensional geometry, incorporating models of all tissues relevant for implant design, and introducing modular designs that increase flexibility/customization.

Conclusions

We found that this surgery simulator was an inexpensive tool that was useful for planning and practicing surgical procedures, as well as prototyping new neuroscience experiment hardware.

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来源期刊

Journal of Neuroscience Methods 医学-神经科学

CiteScore

7.10

自引率

3.30%

发文量

226

审稿时长

52 days

期刊介绍： The Journal of Neuroscience Methods publishes papers that describe new methods that are specifically for neuroscience research conducted in invertebrates, vertebrates or in man. Major methodological improvements or important refinements of established neuroscience methods are also considered for publication. The Journal''s Scope includes all aspects of contemporary neuroscience research, including anatomical, behavioural, biochemical, cellular, computational, molecular, invasive and non-invasive imaging, optogenetic, and physiological research investigations.