不同年龄儿童睡眠剥夺和褪黑素诱发睡眠脑电图的比较：一项随机对照试验

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI:10.1016/j.cnp.2025.09.002

Greta Gustafsson , Martin Ulander , Cornelia Lauermann , Johanna Thegerström , Kathe Dahlbom , Anders Broström , Eva Svanborg , Magnus Vrethem

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引用次数: 0

摘要

目的评价睡眠剥夺和褪黑激素诱发的儿童睡眠脑电图的诊断率可能存在的年龄特异性差异。多中心研究是前瞻性的。方法169例睡眠脑电图患儿按年龄分为2 ~ 5岁、6 ~ 11岁、12 ~ 17岁3组，随机分为褪黑素诱导组和部分剥夺睡眠组。癫痫样活动、睡眠、不良反应和技术记录质量在研究组和年龄组之间进行比较。结果36%的儿童出现癫痫样活动，褪黑激素与睡眠剥夺的脑电图无显著差异。在6 - 11岁儿童中，癫痫样异常发生率为49%，显著高于独立于睡眠诱导方法的其他年龄组。睡眠，而不是睡眠诱导法，与癫痫样活动的存在显著相关（OR 9.16）。褪黑激素诱导后的睡眠发生率（97%）明显高于睡眠剥夺（86%），没有年龄差异。未发现严重的不良反应。结论不同年龄组儿童在褪黑素诱导和睡眠剥夺后脑电图癫痫样活动的发生无明显差异。褪黑素增加了睡眠的可能性。就诊断率而言，褪黑素作为睡眠脑电图的前用药应被认为是安全有效的。

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Comparison between sleep-deprived, and melatonin-induced sleep electroencephalography in children of different ages: a randomized controlled trial

Objective

To evaluate possible age-specific differences in the diagnostic yield of sleep-deprived, and melatonin-induced pediatric sleep EEGs. The multicenter study was performed prospectively.

Methods

Children referred to sleep EEG (n = 169), were stratified into three age groups (2–5; 6–11; 12–17 years) and randomized to sleep induction by melatonin or partial sleep deprivation. Epileptiform activity, sleep, adverse effects, and technical recording quality were compared between study arms and age categories.

Results

Epileptiform activity occurred in 36% of the children, without significant differences between melatonin and sleep-deprived EEGs. In 6–11-year-old children, epileptiform abnormalities occurred in 49%, significantly higher than in the other age groups independent of the sleep-inducing method. Sleep, but not the sleep induction method, was significantly associated with the presence of epileptiform activity (OR 9.16). The occurrence of sleep was significantly higher (97%) after melatonin induction compared to sleep deprivation (86%) without age differences. No serious adverse effects were registered.

Conclusions

There were no differences concerning the occurrence of epileptiform activity in EEG after melatonin induction or sleep deprivation in children of any age category. Melatonin increased the likelihood of sleep.

Significance

Melatonin as a premedication for sleep EEG should be considered safe and efficient in terms of diagnostic yield.

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.