Ralf Jäger, Martin Purpura, Ashok Godavarthi, Halil Ibrahim Ceylan, Sebastian T Balcombe, Ambrish Chandrappa, Grant M Tinsley
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The aim of this study was to evaluate whether a liposomal formulation of CoQ-10 could improve its absorption compared with standard CoQ-10 without the need for the concurrent consumption of fatty foods.</p><p><strong>Methods: </strong>In a randomized, double-blind, placebo-controlled, crossover study design, 7 men and 11 women (<i>n</i> = 18; age: 33.5 ± 6.4 years, height: 171.2 ± 8.1 cm, weight: 65.6 ± 8.8 kg) ingested a single dose of placebo (PLA), 100 mg of unformulated CoQ-10, or 100 mg of liposomal CoQ-10 (Lipo CoQ-10, LipoVantage®, Specnova, LLC, Tyson Corner, VA, USA). Venous blood samples were collected at 0, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 h after ingestion and analyzed for plasma CoQ-10 concentrations.</p><p><strong>Results: </strong>CoQ-10and Lipo CoQ-10 demonstrated significantly greater Cmax and AUC0-24 compared with placebo (<i>p</i> < 0.001). Additionally, Lipo CoQ-10 had significantly higher Cmax (+31.3%, <i>p</i> < 0.001) and AUC0-24 (+22.6%, <i>p</i> < 0.001) values as compared with CoQ-10. CoQ-10 formulations were well-tolerated, with no significant changes in safety markers (blood pressure, renal function, liver enzymes, and lipid profile; <i>p</i> > 0.05), indicating a favorable safety profile.</p><p><strong>Conclusion: </strong>Liposomal delivery significantly enhances CoQ-10 absorption.</p><p><strong>Clinical trial registration: </strong>https://www.ctri.nic.in identifier CTRI/2024/04/066483.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1605033"},"PeriodicalIF":4.0000,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486408/pdf/","citationCount":"0","resultStr":"{\"title\":\"Impact of liposomal delivery on coenzyme Q10 absorption: a double-blind, placebo-controlled, randomized trial.\",\"authors\":\"Ralf Jäger, Martin Purpura, Ashok Godavarthi, Halil Ibrahim Ceylan, Sebastian T Balcombe, Ambrish Chandrappa, Grant M Tinsley\",\"doi\":\"10.3389/fnut.2025.1605033\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Coenzyme Q10 (CoQ-10) plays a vital role in cellular energy production and protection against oxidative stress. 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引用次数: 0
摘要
背景：辅酶Q10 （CoQ-10）在细胞能量生产和抗氧化应激中起着至关重要的作用。然而，由于其水溶性差和相对较大的分子量，口服给药形式的吸收受到限制。虽然将辅酶q -10与富含脂肪的食物一起摄入可以促进吸收，但这种方法并不总是实用的。本研究的目的是评估与标准CoQ-10相比，CoQ-10的脂质体制剂是否可以在不同时食用脂肪食物的情况下改善其吸收。方法:在一项随机,双盲,安慰剂对照,交叉研究设计,7个男性和11个女性(n = 18;年龄:33.5 ±6.4 年,高度:171.2 ± 8.1厘米,体重:65.6 ±8.8 公斤)摄取一剂安慰剂(PLA),没有确立CoQ-10 100毫克,或100 毫克的脂质体CoQ-10(脂肪CoQ-10, LipoVantage®,Specnova, LLC泰森角落,弗吉尼亚州,美国)。在摄食后0、0.5、1、1.5、2、3、4、6、8、12和24 h采集静脉血，分析血浆CoQ-10浓度。结果：CoQ-10和Lipo CoQ-10与安慰剂相比，Cmax和AUC0-24显著增加（p p p p > 0.05），表明其具有良好的安全性。结论：脂质体可显著提高CoQ-10的吸收。临床试验注册：https://www.ctri.nic.in标识符CTRI/2024/04/066483。
Impact of liposomal delivery on coenzyme Q10 absorption: a double-blind, placebo-controlled, randomized trial.
Background: Coenzyme Q10 (CoQ-10) plays a vital role in cellular energy production and protection against oxidative stress. However, its absorption from orally administered forms is limited due to its poor water solubility and relatively large molecular weight. While co-ingesting CoQ-10 with a fatty meal can enhance absorption, this approach is not always practical. The aim of this study was to evaluate whether a liposomal formulation of CoQ-10 could improve its absorption compared with standard CoQ-10 without the need for the concurrent consumption of fatty foods.
Methods: In a randomized, double-blind, placebo-controlled, crossover study design, 7 men and 11 women (n = 18; age: 33.5 ± 6.4 years, height: 171.2 ± 8.1 cm, weight: 65.6 ± 8.8 kg) ingested a single dose of placebo (PLA), 100 mg of unformulated CoQ-10, or 100 mg of liposomal CoQ-10 (Lipo CoQ-10, LipoVantage®, Specnova, LLC, Tyson Corner, VA, USA). Venous blood samples were collected at 0, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 h after ingestion and analyzed for plasma CoQ-10 concentrations.
Results: CoQ-10and Lipo CoQ-10 demonstrated significantly greater Cmax and AUC0-24 compared with placebo (p < 0.001). Additionally, Lipo CoQ-10 had significantly higher Cmax (+31.3%, p < 0.001) and AUC0-24 (+22.6%, p < 0.001) values as compared with CoQ-10. CoQ-10 formulations were well-tolerated, with no significant changes in safety markers (blood pressure, renal function, liver enzymes, and lipid profile; p > 0.05), indicating a favorable safety profile.
期刊介绍：
No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health.
Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.
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