可食用船坞蛋白-多糖胶束传递杨梅素的构建。

IF 3.5 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of the Science of Food and Agriculture Pub Date : 2025-09-29 DOI:10.1002/jsfa.70222

Qian Zhou, Yu-Jia Shen, Shan-Dan Zhao, Lei Cao, Si-Qi Li, Ming Yang, Kang Liu

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引用次数: 0

摘要

背景：杨梅素（Myricetin, Myr）是一种具有抗氧化、抗炎、抗菌、抗病毒和抗肥胖特性的类黄酮化合物，由于其固有的疏水性、热敏性和光敏性，生物利用度有限。为了克服这些限制，我们设计了食用船坞蛋白(EDP)-食用船坞多糖（EDPS）复合胶束，以提高Myr的包封效率和稳定性。结果：EDPS浓度为7.5 g kg-1时，Myr包封率最高，达92.5%。在此条件下，Myr-EDP-EDPS复合胶束的zeta电位为- 21.3 mV，粒径为512.6 nm，多分散性指数为0.35。同时，复合胶束的亲水性和表面张力随EDPS浓度的增加而增加。傅里叶变换红外光谱和x射线衍射光谱结果表明，EDPS被成功地涂覆在Myr-EDP胶束表面。EDPS包封进一步增强了Myr的稳定性，在4°C下保存3个月后保留率达到98.42%，紫外线稳定性提高2.7倍。此外，在Myr-EDP-EDPS复合胶束形成过程中，主要驱动力是氢键和范德华力。体外实验表明，edps包被的Myr- edp复合胶束使Myr的胃稳定性提高了1.38倍，并使其在小肠中有效释放。结论：EDP-EDPS复合胶束体系有效提高了Myr的包封性和稳定性。这种纳米技术代表了一种非常有前途的策略，用于开发具有优化稳定性的功能性食品成分。©2025化学工业协会。

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Construction of edible dock protein-polysaccharide micelles for delivering myricetin.

Background: Myricetin (Myr), a flavonoid compound exhibiting antioxidant, anti-inflammatory, antibacterial, antiviral and anti-obesity properties, suffers from limited bioavailability due to inherent hydrophobicity, thermosensitivity and photosensitivity. To overcome these limitations, we engineered edible dock protein (EDP)-edible dock polysaccharide (EDPS) composite micelles to enhance Myr's encapsulation efficiency and stability.

Results: The highest encapsulation efficiency of Myr was 92.5% when the concentration of EDPS was 7.5 g kg^-1. The zeta potential, particle size and polydispersity index of the Myr-EDP-EDPS composite micelles were - 21.3 mV, 512.6 nm and 0.35 under this condition, respectively. Meanwhile the hydrophilicity and surface tension of the composite micelles were increased with the enhancement of EDPS concentration. Both Fourier transform infrared and X-ray diffraction spectroscopy indicated that EDPS was successfully coated on the surface of the Myr-EDP micelles. The encapsulation by EDPS further enhanced stability of Myr, resulting in 98.42% retention after 3 months at 4 °C and a 2.7-fold increase in ultraviolet stability. In addition, the main driving forces were hydrogen bonding and van der Waals forces during the formation of the Myr-EDP-EDPS composite micelles. In vitro experiments exhibited that the EDPS-coated Myr-EDP composite micelles enhance gastric stability of Myr by 1.38-fold and enable its effective release in the small intestine.

Conclusion: The EDP-EDPS composite micelle system effectively enhances the encapsulation and stability of Myr. This nanotechnology represents a highly promising strategy for developing functional food ingredients featuring optimized stability. © 2025 Society of Chemical Industry.

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.