音乐体验会影响血管内皮对歌唱的反应吗?

IF 2.8 3区 医学 Q3 NEUROSCIENCES
Mehri Bagherimohamadipour, Muhammad Hammad, Alexis Visotcky, Rodney Sparapani, Jacquelyn Kulinski
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引用次数: 0

摘要

背景:血管内皮功能与大脑健康密切相关,特别是在有心血管危险因素的个体中。在一项随机交叉临床试验(NCT04121741)中,我们之前已经表明,30分钟的唱歌可以改善老年冠状动脉疾病患者的微血管内皮功能。在这里,我们报告了二次和探索性分析,包括(1)皮质醇和细胞因子水平的变化及其对血管内皮功能的影响,以及(2)个人音乐体验对血管功能的影响。方法:根据随机、研究者盲法、交叉、对照设计,参与者有三次研究访问,间隔2-7天:(1)与音乐治疗师现场演唱30分钟,(2)30分钟随教学视频唱歌,(3)30分钟休息(对照)。主要结局包括大血管内皮功能通过肱动脉血流介导扩张(BA FMD%)评估,微血管功能通过外周动脉血压计评估[Framingham反应性充血指数(fRHI)和反应性充血指数(RHI)]。探索性结果包括(log)唾液皮质醇和细胞因子(IL-6、TNF-α、IL-1β、IL-8)水平的变化。参与者被要求完成简短的音乐体验问卷(BMEQ),这是一份包含53个项目的自我报告问卷,旨在衡量个人对音乐的整体体验。BMEQ评估人们在生活的各个方面如何感知、反应和参与音乐。结果:65例受试者完成研究,平均年龄67.7±6.6岁,女性占40%。与完成BMEQ的受试者(n = 31)相比,未完成BMEQ的受试者(n = 34)在年龄、性别、种族或是否存在糖尿病、高血压、高胆固醇、心力衰竭、慢性肾脏疾病或慢性呼吸系统疾病方面没有显著差异。BMEQ总分不影响BA FMD%(-3.49±2.00,p = 0.086)、fRHI(0.58±0.93,p = 0.535)和RHI(0.73±0.65,p = 0.262)的变化。当我们分解基于干预、性别、种族和年龄的平方和时,BMEQ评分不能预测血管功能测量的变化。在交叉分析中,与对照组相比,30分钟的歌唱没有引起唾液皮质醇或细胞因子水平的急性变化。IL-8的变化与微血管内皮功能的改变直接相关(RHI组为0.470±0.184,p = 0.012; fRHI组为0.780±0.248,p = 0.002)。TNF-α的变化与fRHI的变化呈负相关(-0.547±0.263,p = 0.040)。皮质醇浓度的变化与血管功能测量无关。结论:老年冠心病患者微血管内皮功能的有益改变不受个人音乐体验的影响。与对照组相比,唱歌30分钟后唾液皮质醇或细胞因子水平没有变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Does Music Experience Impact the Vascular Endothelial Response to Singing?

Background: Vascular endothelial function is closely related to brain health, especially in individuals with cardiovascular risk factors. In a randomized, crossover clinical trial (NCT04121741), we have previously shown that 30 min of singing improves microvascular endothelial function in older adults with coronary artery disease. Here, we report on secondary and exploratory analyses, including (1) changes in cortisol and cytokine levels and their impact on vascular endothelial function, and (2) the impact of personal music experience on vascular function. Methods: Participants had three study visits separated by 2-7 days, according to a randomized, researcher-blinded, crossover, controlled design: (1) a 30-min period of live singing with an in-person music therapist, (2) a 30-min period of singing along to an instructional video and (3) a 30-min rest (control). Primary outcomes included macrovascular endothelial function assessed by brachial artery flow-mediated dilation (BA FMD%) and microvascular function assessed by peripheral arterial tonometry [Framingham reactive hyperemia index (fRHI) and reactive hyperemia index (RHI)]. Exploratory outcomes included (log) changes in salivary cortisol and cytokine (IL-6, TNF-α, IL-1β, IL-8) levels. Participants were asked to complete the Brief Music Experience Questionnaire (BMEQ), a 53-item validated self-report questionnaire designed to measure an individual's overall experience with music. The BMEQ assesses how people perceive, react to, and engage with music in various aspects of their lives. Results: Sixty-five subjects (mean age 67.7 ± 6.6 years, 40% female) completed the study. Compared to those subjects completing the BMEQ (n = 31), there were no significant differences in age, sex, race, or presence of diabetes mellitus, hypertension, high cholesterol, heart failure, chronic kidney disease, or chronic respiratory disease in subjects who did not complete the BMEQ (n = 34). Total BMEQ score did not impact changes in BA FMD% (-3.49 ± 2.00, p = 0.086), changes in fRHI (0.58 ± 0.93, p = 0.535), or changes in RHI (0.73 ± 0.65, p = 0.262). When we decompose the sum of squares based on intervention, sex, race, and age, the BMEQ score does not predict changes in vascular function measures. In cross-over analyses, there were no acute changes in salivary cortisol or cytokine levels with 30 min of singing compared to control. Changes in IL-8 were directly related to changes in microvascular endothelial function (0.470 ± 0.184, p = 0.012 for RHI and 0.780 ± 0.248, p = 0.002 for fRHI). Changes in TNF-α were inversely related to changes in fRHI (-0.547 ± 0.263, p = 0.040). Changes in cortisol concentrations were not related to measures of vascular function. Conclusions: The beneficial changes in microvascular endothelial function are not modified by personal music experience in older subjects with known coronary artery disease. There were no changes in salivary cortisol or cytokine levels after 30 min of singing compared to control.

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来源期刊
Brain Sciences
Brain Sciences Neuroscience-General Neuroscience
CiteScore
4.80
自引率
9.10%
发文量
1472
审稿时长
18.71 days
期刊介绍: Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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