超越潮热:雌激素受体在绝经期心理健康和认知能力下降中的作用。

IF 2.8 3区 医学 Q3 NEUROSCIENCES
Jung Min Cho, Jihye Lee, Eun-Mi Ahn, Jaehoon Bae
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引用次数: 0

摘要

更年期是女性生命中的一个自然阶段,其标志是月经停止,通常伴随着对身心健康产生重大影响的荷尔蒙波动。虽然对更年期的生理症状,如潮热和骨质疏松症给予了很多关注,但对更年期过渡期间激素波动的神经认知后果以及绝经后随后持续的雌激素损失的关注较少。雌激素受体(er),特别是ERα和ERβ,在维持大脑健康、影响情绪、记忆和认知方面起着关键作用。这篇综述探讨了更年期雌激素受体信号传导与心理健康之间的联系,重点关注情绪障碍,如抑郁和焦虑,以及认知能力下降和痴呆。我们讨论了内质网调节脑功能的分子机制,包括它们对神经可塑性、神经递质系统和基因表达的影响。该综述还审查了目前管理更年期认知和心理健康问题的临床方法,包括激素替代疗法和选择性内质网调节剂,同时强调需要进一步研究替代疗法和个性化治疗。雌激素受体在绝经期大脑中的重要性及其作为治疗靶点的潜力被严格评估,旨在阐明更年期和衰老这一经常被忽视的方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Beyond Hot Flashes: The Role of Estrogen Receptors in Menopausal Mental Health and Cognitive Decline.

Menopause is a natural phase in a woman's life marked by the cessation of menstruation, typically accompanied by hormonal fluctuations that have significant impacts on physical and mental health. While much attention has been given to the physical symptoms of menopause, such as hot flashes and osteoporosis, the neurocognitive consequences of hormonal fluctuations during the menopausal transition and the subsequent sustained estrogen loss after menopause have received less focus. Estrogen receptors (ERs), specifically ERα and ERβ, play a critical role in maintaining brain health, influencing mood, memory, and cognition. This review explores the connection between estrogen receptor signaling and mental health during menopause, focusing on mood disorders such as depression and anxiety, as well as cognitive decline and dementia. We discuss the molecular mechanisms by which ERs modulate brain function, including their effects on neuroplasticity, neurotransmitter systems, and gene expression. The review also examines current clinical approaches to managing menopausal cognitive and mental health issues, including hormone replacement therapy and selective ER modulators, while emphasizing the need for further research into alternative therapies and individualized treatments. The importance of estrogen receptors in the menopausal brain and their potential as therapeutic targets is critically evaluated, aiming to shed light on this often-overlooked aspect of menopause and aging.

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来源期刊
Brain Sciences
Brain Sciences Neuroscience-General Neuroscience
CiteScore
4.80
自引率
9.10%
发文量
1472
审稿时长
18.71 days
期刊介绍: Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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