多发性未破裂脑动脉瘤的治疗和预后:描述性队列分析。

IF 2.8 3区 医学 Q3 NEUROSCIENCES
Oday Atallah, Khadeja Alrefaie, Amr Badary
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引用次数: 0

摘要

背景:未破裂的脑动脉瘤由于其潜在的破裂可能导致毁灭性的蛛网膜下腔出血,给神经外科带来了重大挑战。成像技术的进步增加了多个未破裂动脉瘤的意外检测,需要量身定制的管理策略来平衡破裂风险和治疗并发症。方法:我们回顾性分析41例101例未破裂的脑动脉瘤,评估人口统计学、动脉瘤大小和位置、治疗方式和临床结果。描述性统计和相关性分析检查了动脉瘤特征、合并症和治疗后并发症之间的关系。结论:本研究强调了由于多种动脉瘤特征和患者危险因素(如高血压、高脂血症和吸烟),治疗多发未破裂脑动脉瘤的困难。修剪是主要的干预措施,时间根据每个病例定制。尽管出现血管痉挛和神经系统困难等问题,大多数患者仍保持功能独立性。该结果为该患者队列的临床属性、治疗策略和结果提供了重要的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Management and Outcomes of Multiple Unruptured Cerebral Aneurysms: A Descriptive Cohort Analysis.

Background: Unruptured cerebral aneurysms pose a significant neurosurgical challenge due to their potential for rupture, which can lead to devastating subarachnoid hemorrhage. Advances in imaging have increased incidental detection of multiple unruptured aneurysms, necessitating tailored management strategies to balance rupture risk against treatment complications. Methods: We retrospectively analyzed 41 patients with 101 unruptured cerebral aneurysms, assessing demographics, aneurysm size and location, treatment modalities, and clinical outcomes. Descriptive statistics and correlation analyses examined associations between aneurysm characteristics, comorbidities, and post-treatment complications. Results: Most aneurysms were small (<10 mm, 48.5%), primarily located at the Middle Cerebral Artery Bifurcation (27.7%). Hypertension (56.1%) and smoking (53.7%) were prevalent risk factors. Clipping was the most common intervention (81.2%), with 41.4% of patients experiencing post-operative complications and 36.6% developing neurological deficits. Conclusions: This study underscores the difficulties in managing multiple unruptured cerebral aneurysms owing to diverse aneurysm characteristics and patient risk factors such as hypertension, hyperlipidaemia, and smoking. Clipping was the predominant intervention, with time customized for each individual case. Despite the occurrence of problems such as vasospasm and neurological difficulties, the majority of patients maintained functional independence. The results provide significant insights into the clinical attributes, therapeutic strategies, and outcomes for this patient cohort.

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来源期刊
Brain Sciences
Brain Sciences Neuroscience-General Neuroscience
CiteScore
4.80
自引率
9.10%
发文量
1472
审稿时长
18.71 days
期刊介绍: Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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