白质变病的集总参数建模研究表明其血管病理生理可能与常压脑积水相似。

IF 2.8 3区 医学 Q3 NEUROSCIENCES
Grant A Bateman, Alexander R Bateman
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引用次数: 0

摘要

白质病变(LA)或白质疾病是血管性痴呆的重要组成部分。在正常压力脑积水(NPH)和LA之间有很大的重叠。先前报道的NPH的集总参数建模研究导致了这种疾病的新发现。考虑到LA与NPH的重叠,本研究的目的是对LA进行集总参数研究,看看血管病理生理是否与NPH相似。方法:将最初用于研究常压脑积水的集总参数模型扩展到LA。该模型受到来自文献的已知洛杉矶脑血流量和脑血容量的约束。结果:与NPH相似,在LA中,该模型预测动脉和静脉流出阻力平衡增加,导致缺血影响白质而不是灰质。然而,与NPH不同,在LA,结果是不可逆的,很可能是由于结构性静脉壁改变。结论:该模型提示LA的血管生理可能与NPH相似。一种常见的病理生理是基于脉动引起的静脉流出阻力的增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Lumped Parameter Modelling Study of Leukoaraiosis Suggests Its Vascular Pathophysiology May Be Similar to Normal-Pressure Hydrocephalus.

Introduction: Leukoaraiosis (LA) or white matter disease is a significant component of vascular dementia. There is a large overlap noted between normal-pressure hydrocephalus (NPH) and LA. A previously reported lumped parameter modelling study of NPH led to novel findings in this disease. Given the overlap between LA and NPH, the purpose of the current study is to perform a lumped parameter study into LA to see if the vascular pathophysiology is similar to NPH.

Methods: A lumped parameter model originally developed to study normal-pressure hydrocephalus was extended to investigate LA. The model was constrained by the known cerebral blood flow and cerebral blood volumes found in LA, as derived from the literature.

Results: Similar to NPH, in LA, the model predicted a balanced increase in arterial and venous outflow resistance, with the resulting ischemia affecting the white matter rather than the grey matter. However, unlike NPH, in LA, the findings are irreversible, most likely due to structural venous wall changes.

Conclusions: The model suggests that the vascular physiology of LA maybe similar to NPH. A common pathophysiology is discussed based on a pulsation-induced increase in the venous outflow resistance.

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来源期刊
Brain Sciences
Brain Sciences Neuroscience-General Neuroscience
CiteScore
4.80
自引率
9.10%
发文量
1472
审稿时长
18.71 days
期刊介绍: Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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