大叶梓果实的研究。结直肠癌细胞抗氧化、抗炎和抗癌活性与植物化学特征的关系。

IF 6.6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Antioxidants Pub Date : 2025-09-14 DOI:10.3390/antiox14091116

Clizia Bernardi, Thomas Gaslonde, Federica Finetti, Salim Benmaouche, Giulia Macrì, Annabelle Dugay, Claire Cuyamendous, Chouaha Bouzidi, Monica Rosa Loizzo, Philippe Belmont, Rosa Tundis, Lorenza Trabalzini, Brigitte Deguin

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引用次数: 0

摘要

研究了新鲜梓树果实水提物和水提物的化学性质及其潜在的抗炎、抗氧化和抗癌活性。环烯醚萜、类黄酮和酚类化合物是主要的植物化学类。检测到的十种环烯醚萜类化合物中有九种是酰基环烯醚萜类化合物。发现了大量的梓酚和梓苷。通过HPTLC分析和DPPH衍生化，以及DPPH、ABTS、FRAP和β-胡萝卜素漂白等四种体外实验，证明了环烯醚萜类化合物的抗氧化活性。利用体外结直肠癌模型（HT29和HCT166细胞系）评估了大黄姜提取物及其组分的抗癌活性，并重点研究了不同组分对炎症和氧化应激的影响，这是驱动结肠癌发生和发展的关键因素。

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A Study of the Fruits of Catalpa bignonioides Walt.: Evaluation of the Antioxidant, Anti-Inflammatory, and Anti-Cancer Activities in Colorectal Adenocarcinoma Cells in Relation to Phytochemical Profile.

The chemical profiles and potential anti-inflammatory, antioxidant, and anticancer activities of the aqueous extract and fractions of fresh Catalpa bignonioides fruits were studied. Iridoids, flavonoids, and phenolic compounds represent the main phytochemical classes. Nine of the ten iridoids detected are acyl-iridoids. Significant amounts of catalpol and catalposide were found. The antioxidant activity of iridoids was demonstrated by HPTLC analysis coupled with a DPPH derivatization and by applying four in vitro tests, such as DPPH, ABTS, FRAP, and the β-carotene bleaching test. C. bignonioides extract and fractions were also evaluated for their anti-cancer activity using in vitro models of colorectal cancer (HT29 and HCT166 cell lines), and focusing on the effect of the different fractions on inflammation and oxidative stress, key factors that drive the onset and progression of colon cancer.

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来源期刊

Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

10.60

自引率

11.40%

发文量

2123

审稿时长

16.3 days

期刊介绍： Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.