BrainTRACE（脑肿瘤登记和皮质皮质电图）：一种定位脑肿瘤患者皮质电图电极的新工具

IF 2.3 4区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Neuroscience Methods Pub Date : 2025-09-25 DOI:10.1016/j.jneumeth.2025.110588

Sena Oten , Sanjeev Herr , Vardhaan Ambati , Youssef Sibih , Katie Lu , Jasleen Kaur , Shawn L. Hervey-Jumper , David Brang

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引用次数: 0

摘要

术中皮质电图（ECoG）在临床护理和神经科学研究中起着至关重要的作用，可以精确地绘制人类皮层。然而，脑肿瘤患者的硬膜下电极定位面临着独特的挑战，因为神经解剖结构的改变和获得术外成像的不可行性。为了解决这些空白，我们开发了BrainTRACE，这是一种新型的MATLAB工具，它结合了MRI，皮质血管重建和术中摄影来精确地放置硬膜下电极网格。术前记录弥漫性胶质瘤和脑转移患者的MRI、皮质摄影和硬脑膜下电极阵列数据。BrainTRACE生成3D皮质表面，集成血管重建，并实现电极网格的精确放置。每个电极都是根据术中照片显示的皮质解剖结构和血管地标放置的。结果专家用户获得了较高的一致性和准确性，类内相关系数（ICC）为0.934，平均偏差为4.3 mm。新手用户表现出较低的可靠性和较大的可变性，突出了术中ECoG定位的重要性，这需要神经解剖学的专业知识。与现有的方法相比，据我们所知，BrainTRACE是第一个免费使用的工具，它可以通过皮质表面重建和血管解剖，而不依赖于术后成像，实现照片引导的脑电图定位。结论braintrace能够准确定位脑肿瘤患者术中ECoG电极。通过整合解剖图像、术中照片和血管测绘，该工具解决了肿瘤诱发伪影带来的挑战。BrainTRACE为神经外科和神经科学应用提供了一个免费的实用工具，包括脑恶性肿瘤、癫痫和深部脑刺激。

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BrainTRACE (Brain Tumor Registration and Cortical Electrocorticography): A novel tool for localizing electrocorticography electrodes in patients with brain tumors

Background

Intraoperative electrocorticography (ECoG) plays a critical role in clinical care and neuroscience research, enabling precise mapping of human cortex. However, localizing subdural electrodes in patients with brain tumors presents unique challenges due to altered neuroanatomy and the impracticality of acquiring extraoperative imaging.

New method

To address these gaps, we developed BrainTRACE, a novel MATLAB tool that combines MRI, cortical vascular reconstructions, and intraoperative photography for accurate subdural electrode grid placement. Preoperative MRI, cortical photography, and subdural electrode array data were recorded from patients with diffuse glioma and brain metastasis. BrainTRACE generated 3D cortical surfaces, integrated vascular reconstructions, and enabled precise placement of electrode grids. Each electrode was placed based on cortical anatomy and vascular landmarks informed by intraoperative photographs.

Results

Expert users achieved high consistency and accuracy, with an intraclass correlation coefficient (ICC) of 0.934 and a mean deviation of 4.3 mm from consensus placements. Novice users demonstrated lower reliability and greater variability, highlighting the non-trivial nature of intraoperative ECoG localization, which requires neuroanatomical expertise.

Comparison with existing methods

To our knowledge, BrainTRACE is the first freely available tool that enables photograph-guided ECoG localization using cortical surface reconstructions and vascular anatomy without relying on post-operative imaging.

Conclusions

BrainTRACE enables accurate localization of intraoperative ECoG electrodes in brain tumor patients. By integrating anatomical images, intraoperative photographs, and vascular mapping, the tool addresses challenges posed by tumor-induced artifacts. BrainTRACE provides a freely available practical tool for neurosurgical and neuroscience applications, including brain malignancy, epilepsy, and deep brain stimulation.

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来源期刊

Journal of Neuroscience Methods 医学-神经科学

CiteScore

7.10

自引率

3.30%

发文量

226

审稿时长

52 days

期刊介绍： The Journal of Neuroscience Methods publishes papers that describe new methods that are specifically for neuroscience research conducted in invertebrates, vertebrates or in man. Major methodological improvements or important refinements of established neuroscience methods are also considered for publication. The Journal''s Scope includes all aspects of contemporary neuroscience research, including anatomical, behavioural, biochemical, cellular, computational, molecular, invasive and non-invasive imaging, optogenetic, and physiological research investigations.