淋巴系统和脑出血:确定未来治疗进展的分子靶点。

IF 12.4 1区 医学 Q1 CELL BIOLOGY
Ushmita Mukherjee , Sanjana Chowdhury , Kishan Kumar Nagada , MD Mujtahid Hasan , Bijoyani Ghosh , Avdhoot Joshi , Aishika Datta , Jayanta Roy , Pallab Bhattacharya
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引用次数: 0

摘要

淋巴系统是调节大脑健康和清除中枢神经系统(CNS)毒素的重要组成部分。中枢神经系统炎症时,淋巴系统,尤其是血管周围空间发生显著改变。各种脑血管疾病都表明,淋巴功能障碍是脑水肿、神经炎症以及血脑屏障(BBB)损伤的主要因素。脑出血(ICH)是一种主要的危及生命的中风亚型,治疗方法有限。脑出血是由脑动脉破裂、血液积聚和脑实质形成血肿引起的。来自血肿的毒性降解成分进一步加剧了氧化应激、炎症反应和脑水肿,加剧了血脑屏障的破坏以及ich后的神经系统预后。因此,有必要了解继发性脑损伤(SBI)的潜在机制,并制定有针对性的治疗策略,以提高患者的康复。由于淋巴系统参与清除碎片,它可能有助于减轻脑出血后的SBI。在这篇综述中,我们打算更好地了解淋巴系统在减轻SBI中的作用,以及针对该系统改善患者恢复和减少脑出血后损伤的潜在治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Glymphatic system and intracerebral hemorrhage: Identifying molecular targets for future therapeutic advancements
The glymphatic system is an essential component in modulating brain health and clearing out toxins from the central nervous system (CNS). The glymphatic system, especially the perivascular space, undergoes significant alterations during CNS inflammation. Various cerebrovascular disorders have implicated glymphatic dysfunction as the major contributing factor for cerebral edema, neuroinflammation, as well as damage to the blood-brain barrier (BBB). Intracerebral hemorrhage (ICH) is a major life-threatening stroke subtype with limited therapies available. ICH results from the rupture of cerebral arteries, accumulation of the blood and hematoma formation in the brain parenchyma. The toxic degradation components from the hematoma further exacerbates the oxidative stress, inflammatory response and cerebral edema, worsening the BBB disruption as well as the neurological outcomes post-ICH. Thus, making it imperative to understand the underlying mechanisms of secondary brain injury (SBI) and create targeted therapeutic strategies to improve patient recovery. Owing to the involvement of the glymphatic system in clearing out debris, it may contribute in alleviating SBI following ICH. In this review we intend to gain a better understanding of the glymphatic system’s role in mitigating SBI as well as potential therapeutic approaches that target this system to improve patient recovery and reduce damage post-ICH.
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来源期刊
Ageing Research Reviews
Ageing Research Reviews 医学-老年医学
CiteScore
19.80
自引率
2.30%
发文量
216
审稿时长
55 days
期刊介绍: With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.
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