澳大利亚45岁及以上研究中多发性骨髓瘤参与者的医疗系统费用和自体干细胞移植收据。

IF 2.2 4区 医学 Q3 HEMATOLOGY
Sarsha Yap , Anna Kelly , David Goldsbury , Marianne F. Weber , Xue Qin Yu , Qingwei Luo , Karen Canfell , Eleonora Feletto
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引用次数: 0

摘要

背景:在澳大利亚,患有多发性骨髓瘤(MM)的人数预计会增加。我们检查了2006年至2019年澳大利亚45岁及以上研究队列(267,357名参与者)中诊断为MM的参与者的卫生系统成本和自体干细胞移植(ASCT)接收情况。材料和方法:我们使用癌症登记记录确定了520名被诊断为MM的参与者。直接超额卫生系统成本是通过减去2533名没有癌症的匹配参与者观察到的平均值来计算的,从诊断前2年到诊断后5年,计算不同护理阶段和生命结束时的成本。使用伽玛回归分析了与卫生系统成本相关的参与者特征。使用竞争风险回归分析与ASCT接收相关的特征。结果:诊断前一年人均超额卫生系统费用为8846美元,诊断后一年最高为66249美元。从诊断后2年到5年,平均每人额外费用在36,453美元到43,059美元之间,仍然大大高于诊断前的水平。诊断后5年内,125例(24.0 %)接受ASCT。诊断年龄越大与较低的费用(每一年增加,相对率(RR)= 0.97,95 % CI:0.96-0.98初始阶段护理费用)和较低的ASCT率(每一年增加,亚危险比(SHR)= 0.85,95 % CI:0.83-0.87)密切相关。结论:MM患者的医疗系统成本在诊断后明显高于诊断前,并且在至少5年内保持高水平。这项工作为MM的未来医疗保健需求提供了见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Health system costs and autologous stem cell transplant receipt for participants with multiple myeloma in the Australian 45 and Up Study

Background

In Australia, the number of people living with multiple myeloma (MM) is projected to increase. We examined the health system costs and autologous stem cell transplant (ASCT) receipt among participants with MM diagnosed between 2006 and 2019 from the Australian 45 and Up Study cohort (267,357 participants).

Materials and methods

We identified 520 participants diagnosed with MM using cancer registry records. Direct excess health system costs were calculated by subtracting the mean values observed for 2533 matched participants without cancer from those observed for participants with MM. Costs were calculated from 2 years pre-diagnosis up to 5 years post-diagnosis, for different phases of care and at end of life. Participant characteristics associated with health system costs were analysed using gamma regression. Characteristics associated with ASCT receipt were analysed using competing risks regression.

Results

Mean excess health system cost per person was $8846 in the year pre-diagnosis and peaked at $66,249 in the year post-diagnosis. From 2- to 5-years post-diagnosis, mean excess costs per person ranged between $36,453 and $43,059 and remained substantially higher than pre-diagnosis levels. Within the 5-years post-diagnosis, 125 (24.0 %) received ASCT. Older age at diagnosis was strongly associated with lower costs (each one-year increase, relative rate (RR)= 0.97, 95 % CI:0.96–0.98 for initial phase of care costs) and a lower rate of ASCT (each one-year increase, sub-hazard ratio (SHR)= 0.85, 95 % CI:0.83–0.87).

Conclusions

Health system costs for individuals with MM were significantly higher post-diagnosis than pre-diagnosis and remained elevated for at least 5-years. This work provides insights for future healthcare requirements for MM.
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来源期刊
Leukemia research
Leukemia research 医学-血液学
CiteScore
4.00
自引率
3.70%
发文量
259
审稿时长
1 months
期刊介绍: Leukemia Research an international journal which brings comprehensive and current information to all health care professionals involved in basic and applied clinical research in hematological malignancies. The editors encourage the submission of articles relevant to hematological malignancies. The Journal scope includes reporting studies of cellular and molecular biology, genetics, immunology, epidemiology, clinical evaluation, and therapy of these diseases.
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