LGN和V1颜色对抗通路上的BOLD信号分析及POAG和OHT患者光辐射的显微结构改变。

IF 3.7 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2025-09-23 DOI:10.1016/j.brainresbull.2025.111560

Joanne L. Powell , Laura M. Parkes , Anshoo Choudhary , Sophie M. Wuerger

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引用次数: 0

摘要

目的：原发性开角型青光眼（POAG）与外侧膝状核（LGN）和视觉皮层（V1）视网膜神经节细胞丧失和萎缩有关。青光眼的病因和发病机制尚不清楚；高眼压（OHT）患者进展为青光眼的风险增加。为了进一步研究这一点，本研究在POAG和OHT患者的匹配样本中应用了磁反应成像（MRI）。方法：我们招募了53例患者（POAG n=32; OHT n=21），并对POAG （n=9）和OHT （n=9）患者的一个亚组应用功能磁共振成像（fMRI）来测试LGN和初级视觉皮层（V1） BOLD对差异色度调节的反应差异。对弥散加权图像（DWI）应用基于通道的空间统计（TBSS）来比较患者组间全脑分数各向异性（FA）值。沿光辐射（OR）的概率神经束造影测试与OHT患者相比，POAG相关的微结构改变的差异。行为缺陷与POAG对LGN活动的影响也进行了研究。结果：研究结果显示，POAG在三个主要的基本方向上（马格纳-细小通路和孔细胞通路）存在行为缺陷，反映了受体后加工的缺陷。在OHT中观察到LGN和V1活性之间的强相关性，在POAG中显著降低。与OHT相比，POAG中LGN活性增加，而POAG中V1活性略低。DWI显示矢状纹状体和相关视觉WM通路FA显著减少，主要是左半球。与OHT患者相比，POAG患者沿OR的FA减少，结果表明POAG的结构不对称性增强。结论：我们发现POAG和OHT患者组在色对比敏感度和显微结构WM方面存在新的差异。我们的发现揭示了视觉系统中与POAG相关的不对称性的证据，为进一步的研究开辟了几个途径。

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Analysis of the BOLD signal along colour-opponent pathways in LGN and V1 and microstructural alterations of the optic radiation in POAG and OHT patients

Purpose

Primary open angle glaucoma (POAG) is associated with retinal ganglion cell loss and atrophies in the lateral geniculate nucleus (LGN) and visual cortex (V1). The causes and pathogenesis of glaucoma are unclear; with increased risk of progression to glaucoma in patients with ocular hypertension (OHT). To investigate this further the current study applied Magnetic Resonance Imaging (MRI) in a matched sample of POAG and OHT patients.

Method

We recruited 53 patients (POAG n = 32; OHT n = 21) and applied functional-MRI (fMRI) to a sub-group of POAG (n = 9) and OHT (n = 9) patients to test differences in LGN and Primary Visual Cortex (V1) BOLD response to differential chromatic modulations. Tract Based Spatial Statistics (TBSS) was applied to Diffusion weighted images (DWI) to compare fractional anisotropy (FA) values across the whole-brain between patient groups. Probabilistic tractography along the optic radiation (OR) tested for differences in microstructural alterations associated with POAG compared to OHT patients. Behavioural deficits associated with POAG on LGN activity was also investigated.

Results

Findings showed behavioural deficits in POAG in the three major cardinal directions (magno- parvo- and koniocellular pathways), reflecting deficits in post-receptoral processing. Strong correlations were observed between LGN and V1 activity in OHT which was significantly reduced in POAG. Activity in LGN is increased in POAG, whereas V1 activity is slightly lower in POAG compared to OHT. DWI showed significantly reduced FA in sagittal striatum and associated visual WM pathways, primarily of the left hemisphere. Reduced FA along the OR was observed in POAG compared to OHT patients with results indicating enhanced structural asymmetries in POAG.

Conclusion

We present evidence novel differences in chromatic contrast sensitivity and microstructural WM between POAG and OHT patient groups. Our findings reveal evidence for asymmetry within the visual system associated with POAG, opening several avenues for further investigation.

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.