海洋蓝藻降尿酸脂肽的分离与结构分析。

IF 3.6 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2025-09-26 DOI:10.1021/acs.jnatprod.5c01074

Sein Higa, Kazumasa Yagisawa, Noriyuki Natsume, Naoaki Kurisawa, Kiyotake Suenaga, Toshiaki Teruya

{"title":"海洋蓝藻降尿酸脂肽的分离与结构分析。","authors":"Sein Higa, Kazumasa Yagisawa, Noriyuki Natsume, Naoaki Kurisawa, Kiyotake Suenaga, Toshiaki Teruya","doi":"10.1021/acs.jnatprod.5c01074","DOIUrl":null,"url":null,"abstract":"Two linear lipopeptides mabuniamide B (1) and C (2) were isolated from an Okeania sp. marine cyanobacterium collected from the coast of Okinawa. Their structures were elucidated by spectroscopic analyses, and their absolute configurations of amino acid residues were determined using Marfey's analysis of the hydrolysates of 1 and 2. In addition, 1 and 2 inhibited uric acid production in cultured AML12 cells.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Isolation and Structure Elucidation of Uric Acid Lowering Lipopeptides from an Okeania sp. Marine Cyanobacterium.\",\"authors\":\"Sein Higa, Kazumasa Yagisawa, Noriyuki Natsume, Naoaki Kurisawa, Kiyotake Suenaga, Toshiaki Teruya\",\"doi\":\"10.1021/acs.jnatprod.5c01074\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Two linear lipopeptides mabuniamide B (1) and C (2) were isolated from an Okeania sp. marine cyanobacterium collected from the coast of Okinawa. Their structures were elucidated by spectroscopic analyses, and their absolute configurations of amino acid residues were determined using Marfey's analysis of the hydrolysates of 1 and 2. In addition, 1 and 2 inhibited uric acid production in cultured AML12 cells.\",\"PeriodicalId\":47,\"journal\":{\"name\":\"Journal of Natural Products \",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Natural Products \",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1021/acs.jnatprod.5c01074\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Products ","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1021/acs.jnatprod.5c01074","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

摘要

从冲绳海岸的Okeania sp.海洋蓝藻中分离到两个线状脂肽mabuniamide B(1)和C(2)。通过光谱分析确定了它们的结构，并利用1和2水解产物的Marfey分析确定了它们的氨基酸残基绝对构型。此外，1和2抑制培养AML12细胞的尿酸生成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Isolation and Structure Elucidation of Uric Acid Lowering Lipopeptides from an Okeania sp. Marine Cyanobacterium.

Two linear lipopeptides mabuniamide B (1) and C (2) were isolated from an Okeania sp. marine cyanobacterium collected from the coast of Okinawa. Their structures were elucidated by spectroscopic analyses, and their absolute configurations of amino acid residues were determined using Marfey's analysis of the hydrolysates of 1 and 2. In addition, 1 and 2 inhibited uric acid production in cultured AML12 cells.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.