{"title":"小胎龄作为发育协调障碍的预测因子:从日本出生队列联盟探索早期风险","authors":"Hiroyoshi Iwata , Maki Tojo , Kenji J. Tsuchiya , Mami Ishikuro , Geng Chen , Satoshi Suyama , Akio Nakai , Naomi Tamura , Toshio Yoshikawa , Toyoki Yamagata , Tomoko Nishimura , Takeshi Yamaguchi , Keiko Yamazaki , Taku Obara , Kazue Ishitsuka , Naho Morisaki , Keitaro Makino , Shinichi Kuriyama , Reiko Kishi","doi":"10.1016/j.braindev.2025.104435","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Small for gestational age (SGA) and developmental coordination disorder (DCD) are receiving increasing attention in pediatric development. Understanding the risk of DCD, particularly in relation to SGA, would support children's health and development. However, the relationship between SGA and DCD remains unveiled beyond single-cohort studies.</div></div><div><h3>Objectives</h3><div>This study aimed to integrate findings on DCD from different cohorts within the nationwide prospective Japanese Birth Cohort Consortium (JBiCC).</div></div><div><h3>Study design and subjects</h3><div>DCD was assessed in children aged 4 to 7 years from three birth cohorts participating in the JBiCC: the Hokkaido Study on Environment and Children's Health (Hokkaido Study), the Hamamatsu Birth Cohort for Mothers and Children (HBC Study), and the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study).</div></div><div><h3>Outcome measures</h3><div>DCD was assessed using either the Developmental Coordination Disorder Questionnaire Japanese Version (DCDQ-J) or the Ages and Stages Questionnaires Third Edition (ASQ-3). Logistic regression was used to assess the association between SGA and DCD in each cohort. Second, meta-analysis of the association between SGA and DCD defined by DCDQ-J, and individual patient data (IPD) meta-analysis of the association between SGA and DCDQ-J scores were conducted with two cohorts.</div></div><div><h3>Results and conclusions</h3><div>The analysis included 14,233 children in three cohorts. The individual cohort analyses did not explore statistical significance, except for the TMM BirThree Cohort Study. Meta-synthesis of the Hokkaido and HBC studies showed a β-coefficient of −2.63, 95 % CI [−5.22, −0.03]. IPD analysis of linear regression showed a β-coefficient of −2.76, 95 % CI [−5.38, −0.15]. Our results suggest that SGA may be a potential risk factor for DCD.</div></div>","PeriodicalId":56137,"journal":{"name":"Brain & Development","volume":"47 5","pages":"Article 104435"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Small for gestational age as a predictor of developmental coordination disorders: Exploring early risk from Japan birth cohort consortium\",\"authors\":\"Hiroyoshi Iwata , Maki Tojo , Kenji J. Tsuchiya , Mami Ishikuro , Geng Chen , Satoshi Suyama , Akio Nakai , Naomi Tamura , Toshio Yoshikawa , Toyoki Yamagata , Tomoko Nishimura , Takeshi Yamaguchi , Keiko Yamazaki , Taku Obara , Kazue Ishitsuka , Naho Morisaki , Keitaro Makino , Shinichi Kuriyama , Reiko Kishi\",\"doi\":\"10.1016/j.braindev.2025.104435\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Small for gestational age (SGA) and developmental coordination disorder (DCD) are receiving increasing attention in pediatric development. Understanding the risk of DCD, particularly in relation to SGA, would support children's health and development. However, the relationship between SGA and DCD remains unveiled beyond single-cohort studies.</div></div><div><h3>Objectives</h3><div>This study aimed to integrate findings on DCD from different cohorts within the nationwide prospective Japanese Birth Cohort Consortium (JBiCC).</div></div><div><h3>Study design and subjects</h3><div>DCD was assessed in children aged 4 to 7 years from three birth cohorts participating in the JBiCC: the Hokkaido Study on Environment and Children's Health (Hokkaido Study), the Hamamatsu Birth Cohort for Mothers and Children (HBC Study), and the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study).</div></div><div><h3>Outcome measures</h3><div>DCD was assessed using either the Developmental Coordination Disorder Questionnaire Japanese Version (DCDQ-J) or the Ages and Stages Questionnaires Third Edition (ASQ-3). Logistic regression was used to assess the association between SGA and DCD in each cohort. Second, meta-analysis of the association between SGA and DCD defined by DCDQ-J, and individual patient data (IPD) meta-analysis of the association between SGA and DCDQ-J scores were conducted with two cohorts.</div></div><div><h3>Results and conclusions</h3><div>The analysis included 14,233 children in three cohorts. The individual cohort analyses did not explore statistical significance, except for the TMM BirThree Cohort Study. Meta-synthesis of the Hokkaido and HBC studies showed a β-coefficient of −2.63, 95 % CI [−5.22, −0.03]. IPD analysis of linear regression showed a β-coefficient of −2.76, 95 % CI [−5.38, −0.15]. Our results suggest that SGA may be a potential risk factor for DCD.</div></div>\",\"PeriodicalId\":56137,\"journal\":{\"name\":\"Brain & Development\",\"volume\":\"47 5\",\"pages\":\"Article 104435\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain & Development\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0387760425001172\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain & Development","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0387760425001172","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Small for gestational age as a predictor of developmental coordination disorders: Exploring early risk from Japan birth cohort consortium
Background
Small for gestational age (SGA) and developmental coordination disorder (DCD) are receiving increasing attention in pediatric development. Understanding the risk of DCD, particularly in relation to SGA, would support children's health and development. However, the relationship between SGA and DCD remains unveiled beyond single-cohort studies.
Objectives
This study aimed to integrate findings on DCD from different cohorts within the nationwide prospective Japanese Birth Cohort Consortium (JBiCC).
Study design and subjects
DCD was assessed in children aged 4 to 7 years from three birth cohorts participating in the JBiCC: the Hokkaido Study on Environment and Children's Health (Hokkaido Study), the Hamamatsu Birth Cohort for Mothers and Children (HBC Study), and the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study).
Outcome measures
DCD was assessed using either the Developmental Coordination Disorder Questionnaire Japanese Version (DCDQ-J) or the Ages and Stages Questionnaires Third Edition (ASQ-3). Logistic regression was used to assess the association between SGA and DCD in each cohort. Second, meta-analysis of the association between SGA and DCD defined by DCDQ-J, and individual patient data (IPD) meta-analysis of the association between SGA and DCDQ-J scores were conducted with two cohorts.
Results and conclusions
The analysis included 14,233 children in three cohorts. The individual cohort analyses did not explore statistical significance, except for the TMM BirThree Cohort Study. Meta-synthesis of the Hokkaido and HBC studies showed a β-coefficient of −2.63, 95 % CI [−5.22, −0.03]. IPD analysis of linear regression showed a β-coefficient of −2.76, 95 % CI [−5.38, −0.15]. Our results suggest that SGA may be a potential risk factor for DCD.
期刊介绍:
Brain and Development (ISSN 0387-7604) is the Official Journal of the Japanese Society of Child Neurology, and is aimed to promote clinical child neurology and developmental neuroscience.
The journal is devoted to publishing Review Articles, Full Length Original Papers, Case Reports and Letters to the Editor in the field of Child Neurology and related sciences. Proceedings of meetings, and professional announcements will be published at the Editor''s discretion. Letters concerning articles published in Brain and Development and other relevant issues are also welcome.