一种用于测量实验动物皮下肿瘤的3D扫描系统,并扩展应用于黑色素瘤体积测量

IF 2.3 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Aiyue Zhang , Yuke Zhu , Xing Fu , Bo Liu , Jinbin Cui , Yanxian Wu , Yangyun Wang , Leshuai W. Zhang
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引用次数: 0

摘要

在临床前药物开发中,皮下肿瘤体积是评估疾病进展和治疗效果的关键参数。虽然现在有多种技术可用于测量肿瘤体积,但手动卡尺仍然是传统的标准,尽管它们容易产生不准确性和观察者偏差。本研究系统地比较了卡尺与3D扫描获得的肿瘤体积测量的准确性、检测灵敏度和观察者可变性。对粘土模型和肿瘤模型进行分析,以评估测量性能。我们的研究结果表明,与卡尺相比,3D扫描在肿瘤体积量化方面提供了更高的准确性。在粘土模型中,3D扫描与参考体积的相关性更强。体内实验进一步表明,3D扫描减少了测量误差,能够更早地检测到放疗反应,并提高了观察者的再现性。此外,由于光学限制,3D扫描仪最初在深色黑色素瘤和黑色粘土模型上遇到了困难,但白色食品级喷雾剂的应用允许精确的体积测量,从而扩大了该技术在不同肿瘤类型上的适用性。总的来说,这些发现确立了3D扫描作为临床前肿瘤体积测量的一种变革性方法,解决了传统卡尺方法的关键局限性,并最终为研究人员提供了一种更可靠和标准化的癌症研究治疗评估工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A 3D scanning system for measuring subcutaneous tumors in laboratory animals and expanded application to melanoma volume measurements
In preclinical drug development, subcutaneous tumor volume is a critical parameter for evaluating disease progression and therapeutic efficacy. Although multiple techniques are now available for measuring tumor volume, manual calipers—despite their susceptibility to inaccuracy and observer bias—remain the conventional standard. This study systematically compares the accuracy, detection sensitivity, and observer variability of tumor volume measurements obtained via calipers versus 3D scanning. Both clay and tumor models were analyzed to assess measurement performance. Our results demonstrate that 3D scanning provides superior accuracy in tumor volume quantification compared to calipers. In clay models, 3D scanning exhibited stronger correlation with reference volumes. In vivo experiments further revealed that 3D scanning reduced measurement error, enabled earlier detection of radiotherapy responses, and improved observer reproducibility. Additionally, while the 3D scanner initially struggled with dark-colored melanoma and black clay models due to optical limitations, application of white food-grade spraying allowed accurate volumetric measurements, thereby expanding the technology’s applicability across diverse tumor types. Collectively, these findings establish 3D scanning as a transformative approach for preclinical tumor volumetry, addressing the critical limitations of conventional caliper methods, and ultimately providing researchers with a more reliable and standardized tool for therapeutic assessment in cancer studies.
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来源期刊
Medical Engineering & Physics
Medical Engineering & Physics 工程技术-工程:生物医学
CiteScore
4.30
自引率
4.50%
发文量
172
审稿时长
3.0 months
期刊介绍: Medical Engineering & Physics provides a forum for the publication of the latest developments in biomedical engineering, and reflects the essential multidisciplinary nature of the subject. The journal publishes in-depth critical reviews, scientific papers and technical notes. Our focus encompasses the application of the basic principles of physics and engineering to the development of medical devices and technology, with the ultimate aim of producing improvements in the quality of health care.Topics covered include biomechanics, biomaterials, mechanobiology, rehabilitation engineering, biomedical signal processing and medical device development. Medical Engineering & Physics aims to keep both engineers and clinicians abreast of the latest applications of technology to health care.
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