Nathan Runstadler , Selena Martinez , UnCheol Lee , Duan Li , Kourosh Maboudi , George A. Mashour , Phillip E. Vlisides
{"title":"围手术期无线高密度脑电图。","authors":"Nathan Runstadler , Selena Martinez , UnCheol Lee , Duan Li , Kourosh Maboudi , George A. Mashour , Phillip E. Vlisides","doi":"10.1016/j.jneumeth.2025.110584","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Electroencephalographic (EEG) systems used in the operating room are constrained to frontal channels, providing limited neuroanatomical insights into altered perioperative brain states. Our objective is to present pragmatic strategies for placing whole-scalp, high-density EEG systems perioperatively that enable more comprehensive analysis.</div></div><div><h3>New method</h3><div>We present the successful implementation of wireless high-density (72-channel) EEG in the perioperative setting for the ongoing Caffeine, Postoperative Delirium, and Change in Outcomes after Surgery (CAPACHINOS-2) clinical trial (NCT05574400). Placement time was calculated, impedance and data quality were assessed, and data acquisition and analysis pipelines were established. Lastly, proof-of-principle analyses using source localization were conducted.</div></div><div><h3>Results</h3><div>High-density wireless EEG data have been successfully acquired for n = 45 participants, with median (interquartile range) placement time of 34 (25 – 52) minutes. Data acquisition was supported by an established workflow, and a subsequent data processing pipeline was used to evaluate channel quality, remove artifacts, and generate proof-of-principle high-density analyses.</div></div><div><h3>Comparison with existing methods</h3><div>Compared to a low-density system used for a similar, previous clinical trial (n = 54 participants), preoperative median impedance values (kΩ) were lower with the high-density system (13 [11–16] vs. 39 [28–47] kΩ; p < 0.001). Additionally, proof-of-principle analysis demonstrates a more complex connectivity matrix and broader distribution of cortical alpha rhythms after induction of general anesthesia with the high-density system, highlighting an expanded capacity for neurophysiologic analysis.</div></div><div><h3>Conclusions</h3><div>Wireless high-density EEG serves as a feasible, promising tool to advance understanding of altered perioperative brain states by providing high spatiotemporal resolution of cortical oscillations.</div></div>","PeriodicalId":16415,"journal":{"name":"Journal of Neuroscience Methods","volume":"424 ","pages":"Article 110584"},"PeriodicalIF":2.3000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Wireless high-density electroencephalography in the perioperative setting\",\"authors\":\"Nathan Runstadler , Selena Martinez , UnCheol Lee , Duan Li , Kourosh Maboudi , George A. Mashour , Phillip E. Vlisides\",\"doi\":\"10.1016/j.jneumeth.2025.110584\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Electroencephalographic (EEG) systems used in the operating room are constrained to frontal channels, providing limited neuroanatomical insights into altered perioperative brain states. Our objective is to present pragmatic strategies for placing whole-scalp, high-density EEG systems perioperatively that enable more comprehensive analysis.</div></div><div><h3>New method</h3><div>We present the successful implementation of wireless high-density (72-channel) EEG in the perioperative setting for the ongoing Caffeine, Postoperative Delirium, and Change in Outcomes after Surgery (CAPACHINOS-2) clinical trial (NCT05574400). Placement time was calculated, impedance and data quality were assessed, and data acquisition and analysis pipelines were established. Lastly, proof-of-principle analyses using source localization were conducted.</div></div><div><h3>Results</h3><div>High-density wireless EEG data have been successfully acquired for n = 45 participants, with median (interquartile range) placement time of 34 (25 – 52) minutes. Data acquisition was supported by an established workflow, and a subsequent data processing pipeline was used to evaluate channel quality, remove artifacts, and generate proof-of-principle high-density analyses.</div></div><div><h3>Comparison with existing methods</h3><div>Compared to a low-density system used for a similar, previous clinical trial (n = 54 participants), preoperative median impedance values (kΩ) were lower with the high-density system (13 [11–16] vs. 39 [28–47] kΩ; p < 0.001). Additionally, proof-of-principle analysis demonstrates a more complex connectivity matrix and broader distribution of cortical alpha rhythms after induction of general anesthesia with the high-density system, highlighting an expanded capacity for neurophysiologic analysis.</div></div><div><h3>Conclusions</h3><div>Wireless high-density EEG serves as a feasible, promising tool to advance understanding of altered perioperative brain states by providing high spatiotemporal resolution of cortical oscillations.</div></div>\",\"PeriodicalId\":16415,\"journal\":{\"name\":\"Journal of Neuroscience Methods\",\"volume\":\"424 \",\"pages\":\"Article 110584\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Neuroscience Methods\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165027025002286\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neuroscience Methods","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165027025002286","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
Wireless high-density electroencephalography in the perioperative setting
Background
Electroencephalographic (EEG) systems used in the operating room are constrained to frontal channels, providing limited neuroanatomical insights into altered perioperative brain states. Our objective is to present pragmatic strategies for placing whole-scalp, high-density EEG systems perioperatively that enable more comprehensive analysis.
New method
We present the successful implementation of wireless high-density (72-channel) EEG in the perioperative setting for the ongoing Caffeine, Postoperative Delirium, and Change in Outcomes after Surgery (CAPACHINOS-2) clinical trial (NCT05574400). Placement time was calculated, impedance and data quality were assessed, and data acquisition and analysis pipelines were established. Lastly, proof-of-principle analyses using source localization were conducted.
Results
High-density wireless EEG data have been successfully acquired for n = 45 participants, with median (interquartile range) placement time of 34 (25 – 52) minutes. Data acquisition was supported by an established workflow, and a subsequent data processing pipeline was used to evaluate channel quality, remove artifacts, and generate proof-of-principle high-density analyses.
Comparison with existing methods
Compared to a low-density system used for a similar, previous clinical trial (n = 54 participants), preoperative median impedance values (kΩ) were lower with the high-density system (13 [11–16] vs. 39 [28–47] kΩ; p < 0.001). Additionally, proof-of-principle analysis demonstrates a more complex connectivity matrix and broader distribution of cortical alpha rhythms after induction of general anesthesia with the high-density system, highlighting an expanded capacity for neurophysiologic analysis.
Conclusions
Wireless high-density EEG serves as a feasible, promising tool to advance understanding of altered perioperative brain states by providing high spatiotemporal resolution of cortical oscillations.
期刊介绍:
The Journal of Neuroscience Methods publishes papers that describe new methods that are specifically for neuroscience research conducted in invertebrates, vertebrates or in man. Major methodological improvements or important refinements of established neuroscience methods are also considered for publication. The Journal''s Scope includes all aspects of contemporary neuroscience research, including anatomical, behavioural, biochemical, cellular, computational, molecular, invasive and non-invasive imaging, optogenetic, and physiological research investigations.