比较中红外预测能量平衡的遗传结构、一种新的能量缺乏评分和几种生物标志物。

IF 4.4 1区 农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Hongqing Hu, Sébastien Franceschini, Pauline Lemal, Hadi Atashi, Clément Grelet, Yansen Chen, Katrien Wijnrocx, Soyeurt Hélène, Nicolas Gengler
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引用次数: 0

摘要

泌乳早期负能量平衡(NEB)是高产奶牛的一项重要生理挑战,影响奶牛的健康和生产性能。本研究的目的是:(1)利用基于snp的基因组相关分析,比较logit转换的预测NEB (LPNEB)、logit转换的新型能量缺乏评分(LEDS)、15个生物标志物和3个生产性状的遗传结构;(2)将本研究扩展到染色体水平,以确定参与能量代谢调节的特定基因组区域;(3)比较8个性状对LPNEB和LEDS潜在遗传结构的独立贡献。单性状模型估计的SNP效应可用于快速计算20个性状的基因组相关性。结果表明,LPNEB和LEDS之间以及与关键代谢生物标志物,特别是血液非酯化脂肪酸(NEFA)之间存在很强的基因组相关性,突出了它们在能量代谢中的重要性。此外,NEFA是LPNEB和led的强大独立贡献者。BTA19和BTA25的染色体区域与NEB有潜在的关联,结合基因组相关分析和贡献分析,本研究为奶牛NEB及其相关性状的遗传基础提供了有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparing genetic architecture of mid-infrared-predicted energy balance, a novel energy deficiency score, and several biomarkers.

Negative energy balance (NEB) during early lactation is a critical physiological challenge in high-producing dairy cows, affecting both their health and production performance. The objectives of this study were: (1) to compare the genetic architecture of logit-transformed predicted NEB (LPNEB), a logit-transformed novel energy deficiency score (LEDS), 15 biomarkers, and 3 production traits using SNP-based genomic correlation analysis; (2) to extend this study to a chromosomal level to identify specific genomic regions involved in the regulation of energy metabolism; and (3) to compare the independent contributions of 8 traits to the underlying genetic architecture of LPNEB and LEDS. The SNP effects estimated from single-trait models can be used to quickly calculate genomic correlations for 20 traits. The results indicate strong genomic correlations between LPNEB and LEDS, as well as with key metabolic biomarkers, particularly blood nonesterified fatty acids (NEFA), highlighting their importance in energy metabolism. Furthermore, NEFA was a strong independent contributor to both LPNEB and LEDS. Chromosome regions located on BTA19 and BTA25 were identified as potentially associated with NEB. By combining genomic correlation and contribution analyses, this study provides valuable insights into the genetic basis of NEB and related traits in dairy cows.

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来源期刊
Journal of Dairy Science
Journal of Dairy Science 农林科学-奶制品与动物科学
CiteScore
7.90
自引率
17.10%
发文量
784
审稿时长
4.2 months
期刊介绍: The official journal of the American Dairy Science Association®, Journal of Dairy Science® (JDS) is the leading peer-reviewed general dairy research journal in the world. JDS readers represent education, industry, and government agencies in more than 70 countries with interests in biochemistry, breeding, economics, engineering, environment, food science, genetics, microbiology, nutrition, pathology, physiology, processing, public health, quality assurance, and sanitation.
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