Emmanuel Drouin, Patrick Hautecoeur, Arnaud Kwiatkowski
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Jean-Martin Charcot and the Clinical Foundations of Amyotrophic Lateral Sclerosis: A Historical Case Revisited.
We revisit a landmark clinical case recorded by Jean-Martin Charcot in 1877-78, describing a patient with bulbar-onset amyotrophic lateral sclerosis (ALS). This case offers a rich window into Charcot's observational method, clinical reasoning, and early neuropathological insights. We discuss the methodological rigor of Charcot's case analysis and place it in dialogue with modern understandings of ALS pathophysiology, diagnosis, and care. This historical reflection highlights how 19th-century neurology laid the foundation for current multidisciplinary approaches to managing neurodegenerative diseases.
期刊介绍:
''European Neurology'' publishes original papers, reviews and letters to the editor. Papers presented in this journal cover clinical aspects of diseases of the nervous system and muscles, as well as their neuropathological, biochemical, and electrophysiological basis. New diagnostic probes, pharmacological and surgical treatments are evaluated from clinical evidence and basic investigative studies. The journal also features original works and reviews on the history of neurology.