基于有限元模拟和代理模型的冠脉辅助支架多目标优化。

IF 1.6 4区医学 Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-09-09 DOI:10.1080/10255842.2025.2556003

Yanyan Wan, Xiaoyan Liu, Kuangrong Hao, Yicun Hua

{"title":"基于有限元模拟和代理模型的冠脉辅助支架多目标优化。","authors":"Yanyan Wan, Xiaoyan Liu, Kuangrong Hao, Yicun Hua","doi":"10.1080/10255842.2025.2556003","DOIUrl":null,"url":null,"abstract":"High cost of clinical trials hinders further enhancement of comprehensive mechanical properties of bioresorbable scaffolds (BRS). Therefore, a multi-objective optimization method combining surrogate modeling and finite element simulation is proposed, based on the evaluation of stents with various auxetic structures and materials. The results demonstrated that re-entrant hexagon stent made of PLA (PLA-RH stent) was a more ideal candidate, with superior radial recoil and force. Following optimization, PLA-RH stent decreased bending stiffness by 60.12%, without compromising radial performances. This method enables more precise and efficient optimization and the proposed auxetic structure introduces innovative concepts for future design of stents.","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-16"},"PeriodicalIF":1.6000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multi-objective optimization of auxetic coronary stents based on finite element simulation and surrogate modeling.\",\"authors\":\"Yanyan Wan, Xiaoyan Liu, Kuangrong Hao, Yicun Hua\",\"doi\":\"10.1080/10255842.2025.2556003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"High cost of clinical trials hinders further enhancement of comprehensive mechanical properties of bioresorbable scaffolds (BRS). Therefore, a multi-objective optimization method combining surrogate modeling and finite element simulation is proposed, based on the evaluation of stents with various auxetic structures and materials. The results demonstrated that re-entrant hexagon stent made of PLA (PLA-RH stent) was a more ideal candidate, with superior radial recoil and force. Following optimization, PLA-RH stent decreased bending stiffness by 60.12%, without compromising radial performances. This method enables more precise and efficient optimization and the proposed auxetic structure introduces innovative concepts for future design of stents.\",\"PeriodicalId\":50640,\"journal\":{\"name\":\"Computer Methods in Biomechanics and Biomedical Engineering\",\"volume\":\" \",\"pages\":\"1-16\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-09-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Computer Methods in Biomechanics and Biomedical Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1080/10255842.2025.2556003\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computer Methods in Biomechanics and Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1080/10255842.2025.2556003","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS","Score":null,"Total":0}

引用次数: 0

摘要

高成本的临床试验阻碍了生物可吸收支架（BRS）综合力学性能的进一步提高。因此，在对各种结构和材料的辅助支架进行评价的基础上，提出了一种代理建模和有限元仿真相结合的多目标优化方法。结果表明，聚乳酸再入式六边形支架（PLA- rh支架）具有较好的径向后坐力和受力，是较理想的支架材料。优化后，PLA-RH支架在不影响径向性能的情况下，弯曲刚度降低了60.12%。该方法可以实现更精确和高效的优化，所提出的辅助结构为未来的支架设计引入了创新的概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Multi-objective optimization of auxetic coronary stents based on finite element simulation and surrogate modeling.

High cost of clinical trials hinders further enhancement of comprehensive mechanical properties of bioresorbable scaffolds (BRS). Therefore, a multi-objective optimization method combining surrogate modeling and finite element simulation is proposed, based on the evaluation of stents with various auxetic structures and materials. The results demonstrated that re-entrant hexagon stent made of PLA (PLA-RH stent) was a more ideal candidate, with superior radial recoil and force. Following optimization, PLA-RH stent decreased bending stiffness by 60.12%, without compromising radial performances. This method enables more precise and efficient optimization and the proposed auxetic structure introduces innovative concepts for future design of stents.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Computer Methods in Biomechanics and Biomedical Engineering 工程技术-工程：生物医学

CiteScore

4.10

自引率

6.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： The primary aims of Computer Methods in Biomechanics and Biomedical Engineering are to provide a means of communicating the advances being made in the areas of biomechanics and biomedical engineering and to stimulate interest in the continually emerging computer based technologies which are being applied in these multidisciplinary subjects. Computer Methods in Biomechanics and Biomedical Engineering will also provide a focus for the importance of integrating the disciplines of engineering with medical technology and clinical expertise. Such integration will have a major impact on health care in the future.