Jae Sang Han, , , Jun Gu Kim, , , Yong Beom Cho, , , Joon Su Jang, , , Vu Quan Dang, , , Dongho Lee, , , Mi Kyeong Lee, , , Jin Woo Lee, , and , Bang Yeon Hwang*,
{"title":"菟丝子四糖树脂苷对一氧化氮生成抑制活性的研究。","authors":"Jae Sang Han, , , Jun Gu Kim, , , Yong Beom Cho, , , Joon Su Jang, , , Vu Quan Dang, , , Dongho Lee, , , Mi Kyeong Lee, , , Jin Woo Lee, , and , Bang Yeon Hwang*, ","doi":"10.1021/acs.jnatprod.5c00713","DOIUrl":null,"url":null,"abstract":"<p >LC-HRMS/MS-based molecular-network-guided chemical investigation of <i>Cuscuta campestris</i> led to the isolation of seven undescribed tetrasaccharide-type resin glycosides (<b>1</b>–<b>7</b>). Their structures were elucidated using 1D and 2D NMR and HRESIMS analysis. Isolated resin glycosides were comprised of <span>d</span>-glucose, <span>d</span>-fucose, <span>d</span>-quinovose, and <span>l</span>-rhamnose, and these monosaccharides were partially acylated with acetyl, isobutyryl, <i>n</i>-hexanoyl, and niloyl organic acids. The absolute configuration of aglycones were determined as <i>S</i>-configuration using Mosher’s method after acid hydrolysis of resin glycoside fraction. All compounds were evaluated for their inhibitory activity against the production of nitric oxide in RAW 264.7 cells. Compounds <b>2</b> and <b>3</b> exhibited inhibitory activity, with IC<sub>50</sub> values of 14.3 and 10.4 μM, respectively.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":"88 9","pages":"2117–2126"},"PeriodicalIF":3.6000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tetrasaccharide Resin Glycosides with Nitric Oxide Production Inhibitory Activity from Cuscuta campestris\",\"authors\":\"Jae Sang Han, , , Jun Gu Kim, , , Yong Beom Cho, , , Joon Su Jang, , , Vu Quan Dang, , , Dongho Lee, , , Mi Kyeong Lee, , , Jin Woo Lee, , and , Bang Yeon Hwang*, \",\"doi\":\"10.1021/acs.jnatprod.5c00713\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >LC-HRMS/MS-based molecular-network-guided chemical investigation of <i>Cuscuta campestris</i> led to the isolation of seven undescribed tetrasaccharide-type resin glycosides (<b>1</b>–<b>7</b>). Their structures were elucidated using 1D and 2D NMR and HRESIMS analysis. Isolated resin glycosides were comprised of <span>d</span>-glucose, <span>d</span>-fucose, <span>d</span>-quinovose, and <span>l</span>-rhamnose, and these monosaccharides were partially acylated with acetyl, isobutyryl, <i>n</i>-hexanoyl, and niloyl organic acids. The absolute configuration of aglycones were determined as <i>S</i>-configuration using Mosher’s method after acid hydrolysis of resin glycoside fraction. All compounds were evaluated for their inhibitory activity against the production of nitric oxide in RAW 264.7 cells. Compounds <b>2</b> and <b>3</b> exhibited inhibitory activity, with IC<sub>50</sub> values of 14.3 and 10.4 μM, respectively.</p>\",\"PeriodicalId\":47,\"journal\":{\"name\":\"Journal of Natural Products \",\"volume\":\"88 9\",\"pages\":\"2117–2126\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-09-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Natural Products \",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.jnatprod.5c00713\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Products ","FirstCategoryId":"99","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.jnatprod.5c00713","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Tetrasaccharide Resin Glycosides with Nitric Oxide Production Inhibitory Activity from Cuscuta campestris
LC-HRMS/MS-based molecular-network-guided chemical investigation of Cuscuta campestris led to the isolation of seven undescribed tetrasaccharide-type resin glycosides (1–7). Their structures were elucidated using 1D and 2D NMR and HRESIMS analysis. Isolated resin glycosides were comprised of d-glucose, d-fucose, d-quinovose, and l-rhamnose, and these monosaccharides were partially acylated with acetyl, isobutyryl, n-hexanoyl, and niloyl organic acids. The absolute configuration of aglycones were determined as S-configuration using Mosher’s method after acid hydrolysis of resin glycoside fraction. All compounds were evaluated for their inhibitory activity against the production of nitric oxide in RAW 264.7 cells. Compounds 2 and 3 exhibited inhibitory activity, with IC50 values of 14.3 and 10.4 μM, respectively.
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
