Finite element simulation of lung parenchyma deformation based on porcine data.

Accurate modeling of lung parenchymal biomechanics is critical for understanding respiratory function and improving diagnoses. Traditional hyperelastic models capture tissue deformation but miss essential physiological interactions. This study evaluates an experimentally informed poroelastic model (Birzle's formulation) against hyperelastic-only models within a finite element framework. Using porcine lung geometry and CT-based boundary conditions, we simulate realistic breathing cycles and compare deformation, stress, strain, and volume change. Results show that poroelasticity better reproduces pressure-volume behavior and ventilation distribution, underscoring the importance of fluid-influenced mechanics for robust, clinically relevant lung modeling.