{"title":"脑力劳动与生物衰老的关系：内脏脂肪指数的中介作用。","authors":"Kangnan Zhang, Rongdi Xu, Yuhe Liu, Wenqian Wu, Yong Zhou","doi":"10.1093/geroni/igaf077","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objectives: </strong>This study aimed to investigate the relationship between mental work, work intensity, and accelerated biological aging, focusing on the mediating role of the Visceral Adiposity Index (VAI).</p><p><strong>Research design and methods: </strong>In this cross-sectional study, data were collected from the Kailuan physical activity cohorts in the Asia-Pacific region. Biological aging was assessed using PhenoAge and Klemera-Doubal method age (KDMAge) acceleration. Multivariable linear regression models examined the link between mental work and biological aging, while mediation analysis assessed the role of VAI.</p><p><strong>Results: </strong>Among 3,933 participants (mean age 56.4 years; 55.6% male), mental workers showed greater biological age (BA) acceleration: KDMAge acceleration increased by 1.52 years (<i>p</i> for trend = .04) and PhenoAge by 1.46 years (<i>p</i> for trend < .001) compared to manual workers, after adjusting for age and sex. In mental workers, high labor intensity was associated with greater BA acceleration: KDMAge β = 0.40, 95% CI [0.10-0.65]; PhenoAge β = 0.51, 95% CI [0.10-1.38]. In manual workers, high labor intensity also correlated with increased BA acceleration: KDMAge β = 1.53, 95% CI [0.91-2.12]; PhenoAge β = 1.32, 95% CI [0.37-2.26]. Mediation analysis showed that VAI mediated 9.8% of the mental work-PhenoAge relationship and 20.9% of the KDMAge relationship.</p><p><strong>Discussion and implications: </strong>Mental work is associated with accelerated biological aging. These results highlight the importance of interventions targeting work intensity and metabolic health to reduce age-related disease burdens.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"9 8","pages":"igaf077"},"PeriodicalIF":4.3000,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409274/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between mental work and biological aging: the mediating role of visceral adiposity index.\",\"authors\":\"Kangnan Zhang, Rongdi Xu, Yuhe Liu, Wenqian Wu, Yong Zhou\",\"doi\":\"10.1093/geroni/igaf077\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objectives: </strong>This study aimed to investigate the relationship between mental work, work intensity, and accelerated biological aging, focusing on the mediating role of the Visceral Adiposity Index (VAI).</p><p><strong>Research design and methods: </strong>In this cross-sectional study, data were collected from the Kailuan physical activity cohorts in the Asia-Pacific region. Biological aging was assessed using PhenoAge and Klemera-Doubal method age (KDMAge) acceleration. Multivariable linear regression models examined the link between mental work and biological aging, while mediation analysis assessed the role of VAI.</p><p><strong>Results: </strong>Among 3,933 participants (mean age 56.4 years; 55.6% male), mental workers showed greater biological age (BA) acceleration: KDMAge acceleration increased by 1.52 years (<i>p</i> for trend = .04) and PhenoAge by 1.46 years (<i>p</i> for trend < .001) compared to manual workers, after adjusting for age and sex. In mental workers, high labor intensity was associated with greater BA acceleration: KDMAge β = 0.40, 95% CI [0.10-0.65]; PhenoAge β = 0.51, 95% CI [0.10-1.38]. In manual workers, high labor intensity also correlated with increased BA acceleration: KDMAge β = 1.53, 95% CI [0.91-2.12]; PhenoAge β = 1.32, 95% CI [0.37-2.26]. Mediation analysis showed that VAI mediated 9.8% of the mental work-PhenoAge relationship and 20.9% of the KDMAge relationship.</p><p><strong>Discussion and implications: </strong>Mental work is associated with accelerated biological aging. These results highlight the importance of interventions targeting work intensity and metabolic health to reduce age-related disease burdens.</p>\",\"PeriodicalId\":13596,\"journal\":{\"name\":\"Innovation in Aging\",\"volume\":\"9 8\",\"pages\":\"igaf077\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409274/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Innovation in Aging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/geroni/igaf077\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Innovation in Aging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/geroni/igaf077","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Association between mental work and biological aging: the mediating role of visceral adiposity index.
Background and objectives: This study aimed to investigate the relationship between mental work, work intensity, and accelerated biological aging, focusing on the mediating role of the Visceral Adiposity Index (VAI).
Research design and methods: In this cross-sectional study, data were collected from the Kailuan physical activity cohorts in the Asia-Pacific region. Biological aging was assessed using PhenoAge and Klemera-Doubal method age (KDMAge) acceleration. Multivariable linear regression models examined the link between mental work and biological aging, while mediation analysis assessed the role of VAI.
Results: Among 3,933 participants (mean age 56.4 years; 55.6% male), mental workers showed greater biological age (BA) acceleration: KDMAge acceleration increased by 1.52 years (p for trend = .04) and PhenoAge by 1.46 years (p for trend < .001) compared to manual workers, after adjusting for age and sex. In mental workers, high labor intensity was associated with greater BA acceleration: KDMAge β = 0.40, 95% CI [0.10-0.65]; PhenoAge β = 0.51, 95% CI [0.10-1.38]. In manual workers, high labor intensity also correlated with increased BA acceleration: KDMAge β = 1.53, 95% CI [0.91-2.12]; PhenoAge β = 1.32, 95% CI [0.37-2.26]. Mediation analysis showed that VAI mediated 9.8% of the mental work-PhenoAge relationship and 20.9% of the KDMAge relationship.
Discussion and implications: Mental work is associated with accelerated biological aging. These results highlight the importance of interventions targeting work intensity and metabolic health to reduce age-related disease burdens.
期刊介绍：
Innovation in Aging, an interdisciplinary Open Access journal of the Gerontological Society of America (GSA), is dedicated to publishing innovative, conceptually robust, and methodologically rigorous research focused on aging and the life course. The journal aims to present studies with the potential to significantly enhance the health, functionality, and overall well-being of older adults by translating scientific insights into practical applications. Research published in the journal spans a variety of settings, including community, clinical, and laboratory contexts, with a clear emphasis on issues that are directly pertinent to aging and the dynamics of life over time. The content of the journal mirrors the diverse research interests of GSA members and encompasses a range of study types. These include the validation of new conceptual or theoretical models, assessments of factors impacting the health and well-being of older adults, evaluations of interventions and policies, the implementation of groundbreaking research methodologies, interdisciplinary research that adapts concepts and methods from other fields to aging studies, and the use of modeling and simulations to understand factors and processes influencing aging outcomes. The journal welcomes contributions from scholars across various disciplines, such as technology, engineering, architecture, economics, business, law, political science, public policy, education, public health, social and psychological sciences, biomedical and health sciences, and the humanities and arts, reflecting a holistic approach to advancing knowledge in gerontology.
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