原发性皮肤大汗腺癌转移至食道的乳腺外佩吉特病的新组织学特征。

IF 1.1 4区 医学 Q3 DERMATOLOGY
Dre Barnachea, Maki Yamamoto, Rupali Banker, Dong Ren, Bonnie Lee
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引用次数: 0

摘要

原发性皮肤大汗腺癌(PCAC)是一种罕见的皮肤恶性肿瘤起源于大汗腺,最常见于腋窝和肛门生殖器区域。它通常遵循缓慢增长的临床过程,尽管在某些病例中记录了攻击行为。虽然局部复发和局部转移在PCAC中并不罕见,但远处转移的病例很少,只有少数病例报道,包括肝、骨和肺的转移。我们报告一个独特的PCAC病例,其腹股沟出现页状特征并转移到食道,这是一种非常不寻常的表现,在现有文献中没有很好地描述。PCAC表现为乳腺外佩吉特病(EMPD),其特征是单个恶性上皮细胞分散在整个表皮,是一种罕见且具有诊断挑战性的变体。它能够模拟来自不同器官的转移性癌,需要彻底的临床和病理关联才能准确诊断。本病例报告旨在阐明PCAC的潜在攻击行为,并强调需要长期监测和意识到其不太典型的表现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Novel Histopathologic Features of Extramammary Paget's Disease in Metastatic Primary Cutaneous Apocrine Carcinoma to the Esophagus.

Primary cutaneous apocrine carcinoma (PCAC) is an exceptionally rare cutaneous malignancy originating from apocrine glands, occurring most commonly in the axilla and anogenital regions. It typically follows a slow-growing clinical course, although aggressive behavior has been documented in select cases. While local recurrence and regional metastasis are not uncommon in PCAC, instances of distant metastases are rare, with only a handful of cases reported, including involvement of the liver, bone, and lung. We present a unique case of PCAC with pagetoid features arising in the groin and metastasizing to the esophagus, a highly unusual presentation not well described in the existing literature. PCAC manifesting as extramammary Paget's disease (EMPD), characterized by single malignant epithelial cells scattered throughout the epidermis, represents a rare and diagnostically challenging variant. Its ability to mimic metastatic carcinomas from various organs necessitates thorough clinical and pathological correlation for accurate diagnosis. This case report aims to illuminate the potentially aggressive behavior of PCAC and emphasizes the need for long-term surveillance and awareness of its less typical presentations.

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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
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