优化纳米颗粒设计选择性靶向乳腺癌细胞

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Medical Engineering & Physics Pub Date : 2025-09-02 DOI:10.1016/j.medengphy.2025.104420

Sarah Iaquinta , Shahram Khazaie , Sylvain Fréour , Frédéric Jacquemin

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引用次数: 0

摘要

最近的癌症靶向研究主要集中在纳米颗粒（NP）药物递送上，然而纳米颗粒摄取的复杂性使得实验研究具有挑战性。为了简化这一过程，数值模型帮助确定关键参数。本研究的模型，专注于椭圆NP，旨在优化NP的纵横比选择性摄取乳腺癌细胞。从文献中获取细胞的力学特性，该模型表明，长宽比在1/3和1/2之间的不可变形NPs最适合选择性癌细胞内化。这些有希望的结果需要实验验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Optimizing nanoparticle design for selective targeting of breast cancer cells

Recent efforts in cancer targeting have focused on nanoparticle (NP) drug delivery, yet the complexity of NP uptake makes experimental studies challenging. To streamline this, numerical models help identify key parameters. This study's model, focusing on elliptical NPs, aims to optimize NP aspect ratios for selective uptake by breast cancer cells. Mechanical properties of cells were taken from literature, and the model suggests that non-deformable NPs with aspect ratios between 1/3 and 1/2 are optimal for selective cancer cell internalization. These promising results require experimental validation.

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来源期刊

Medical Engineering & Physics 工程技术-工程：生物医学

CiteScore

4.30

自引率

4.50%

发文量

172

审稿时长

3.0 months

期刊介绍： Medical Engineering & Physics provides a forum for the publication of the latest developments in biomedical engineering, and reflects the essential multidisciplinary nature of the subject. The journal publishes in-depth critical reviews, scientific papers and technical notes. Our focus encompasses the application of the basic principles of physics and engineering to the development of medical devices and technology, with the ultimate aim of producing improvements in the quality of health care.Topics covered include biomechanics, biomaterials, mechanobiology, rehabilitation engineering, biomedical signal processing and medical device development. Medical Engineering & Physics aims to keep both engineers and clinicians abreast of the latest applications of technology to health care.