{"title":"氧化应激反应蛋白通过促进应激颗粒清除延缓卵巢衰老。","authors":"","doi":"10.1038/s43587-025-00960-9","DOIUrl":null,"url":null,"abstract":"Analysis of granulosa cells from participants with age-related or pathological ovarian aging identified a crucial factor — NCOA7 — that promotes stress granule clearance via autophagy (‘granulophagy’), conferring protection against ovarian aging. Boosting NCOA7 activity or granulophagy alleviates senescence in granulosa cells and delays ovarian aging, suggesting new therapeutic strategies.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 9","pages":"1667-1668"},"PeriodicalIF":19.4000,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Oxidative stress response protein delays ovarian aging by promoting stress granule clearance\",\"authors\":\"\",\"doi\":\"10.1038/s43587-025-00960-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Analysis of granulosa cells from participants with age-related or pathological ovarian aging identified a crucial factor — NCOA7 — that promotes stress granule clearance via autophagy (‘granulophagy’), conferring protection against ovarian aging. Boosting NCOA7 activity or granulophagy alleviates senescence in granulosa cells and delays ovarian aging, suggesting new therapeutic strategies.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":\"5 9\",\"pages\":\"1667-1668\"},\"PeriodicalIF\":19.4000,\"publicationDate\":\"2025-08-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-025-00960-9\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-025-00960-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Oxidative stress response protein delays ovarian aging by promoting stress granule clearance
Analysis of granulosa cells from participants with age-related or pathological ovarian aging identified a crucial factor — NCOA7 — that promotes stress granule clearance via autophagy (‘granulophagy’), conferring protection against ovarian aging. Boosting NCOA7 activity or granulophagy alleviates senescence in granulosa cells and delays ovarian aging, suggesting new therapeutic strategies.
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