芦荟多糖通过修复肠道屏障和调节肠道菌群来缓解小鼠便秘。

IF 3.5 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of the Science of Food and Agriculture Pub Date : 2025-09-01 DOI:10.1002/jsfa.70108

Ke Liu, Yuying Zhang, Han Cai, Shuang Song, Chunqing Ai, Jingfeng Yang

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引用次数: 0

摘要

背景：便秘是社会常见病，渗透性泻药能有效缓解症状。但不适合长期使用。膳食纤维是另一种选择，具有解决肠道屏障功能障碍和持续微生物生态失调的能力。ULP是一种海藻纤维。它含有高醛醛酸和硫酸盐基团，可能有助于缓解便秘，因为它有很强的保水能力。结果：给药0.1 g kg-1 ULP可提高小鼠粪便含水量和胃肠推进率。增强亲水性相互作用，恢复肠道动力相关肽；胃动素、胃泌素和5-羟色胺分别上升50.71%、123.70%和185.74%。ULP还能使TNF-α和IL-6炎症因子分别降低37.8%和49.1%，维持肠道屏障的完整性。16S rRNA测序和代谢组学分析显示，ULP使乳酸菌（Lactobacillus）和Muribaculum的富集量分别增加了7.6倍和5.4倍。它协同提高精氨酸和s -腺苷蛋氨酸的水平。结论：ULP可通过水潴留、微生物调节和代谢信号调节缓解便秘。它为便秘管理提供了一种新颖的多目标策略。©2025化学工业协会。

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Ulva lactuca polysaccharides alleviate constipation in mice through repairing the intestinal barrier and regulating the gut microbiota.

Background: Constipation is a frequent chronic disease in the community, and osmotic laxatives can effectively alleviate symptoms. However, it is not suitable for long-term use. Dietary fiber is an alternative option, with a capacity to address intestinal barrier dysfunction and sustained microbial dysbiosis. Ulva lactuca polysaccharide (ULP) is an algal fiber. It contains high alduronic acid and sulfate groups and may contribute to constipation alleviation owing to its strong water retention capabilities.

Results: Administration of 0.1 g kg^-1 ULP to mice increased fecal water content and gastrointestinal propulsion rate. It enhanced hydrophilic interactions and restored intestinal motility-related peptides; motilin, gastrin and 5-hydroxytryptamine rose by 50.71%, 123.70% and 185.74%, respectively. ULP also decreased the TNF-α and IL-6 inflammatory factors by 37.8% and 49.1%, and sustained the integrity of the intestinal barrier. The 16S rRNA sequencing and metabolomics showed that ULP enhanced the enrichment of Lactobacillus (7.6-fold) and Muribaculum (5.4-fold). It synergistically increased levels of arginine and S-adenosylmethionine.

Conclusion: ULP alleviated constipation by water retention, microbial modulation and metabolic signaling regulation. It offers a novel, multi-target strategy for constipation management. © 2025 Society of Chemical Industry.

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.