紫薇亚种的生物活性特性。variegata (Willd)。P.H. Davis，豆科：抗氧化剂，抗帕金森病及其与食品和农业用途的相关性。

IF 3.5 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of the Science of Food and Agriculture Pub Date : 2025-08-24 DOI:10.1002/jsfa.70140

Bilge Aydın, Muhammed Sait Ertuğrul, İsmail Çağrı Aydın, Rüstem Anıl Uğan, Mustafa Özkaraca, Hafize Yuca, Hilal Özbek, Cavit Kazaz, Ufuk Okkay, Songül Karakaya, Ahmet Hacımüftüoğlu, Zühal Güvenalp

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引用次数: 0

摘要

背景：豆科蚕豆属的多种蚕豆属植物在世界不同地区被广泛用于人类营养和动物饲料，在预防和治疗多种疾病方面也具有药理潜力。从这一角度出发，本研究探讨了紫穗槐亚种提取物的抗帕金森作用。在细胞培养和6-羟多巴胺（6-OHDA）诱导的帕金森模型大鼠身上研究了多种变异。通过生化和组织病理学分析，评价了该植物对帕金森病病理生理的影响；此外，对活性提取物中化合物的结构进行了分析，并测定了这些化合物的体外抗氧化和抗帕金森病活性。结果：从蛇麻属植物的地上部位制备甲醇和正丁醇提取物。Variegata在细胞培养和大鼠模型中均显示出显著的抗帕金森作用。组织病理学和生化分析也与体内实验平行。作为分离研究的结果，从该植物中获得了6种黄酮醇苷，并随后评估了它们的抗氧化能力和抗帕金森病作用。槲皮素-3- o -α-l-rhamnopyranoside （quercitrin, VCB-3）的生物学效应最高。结论：根据研究结果，蛇弧菌亚群具有抗帕金森病的作用。评估变异。可以看出，它们可以防止神经变性和氧化应激的发生，并确定了最有效的化合物。这一研究结果为文献添加了两种新的化合物，分别命名为水仙花苷A和B。©2025化学工业协会。

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Bioactive properties of Vicia canescens subsp. variegata (Willd.) P.H. Davis, Fabaceae: antioxidant, antiparkinsonian and relevance to food and agriculture use.

Background: Various Vicia species belonging to the Fabaceae family are known to be used in different parts of the world both in human nutrition and as animal feed, and also have pharmacological potential in the prevention and treatment of various diseases. With this perspective, in the present study, the possible antiparkinsonian effects of extracts prepared from Vicia canescens subsp. variegata were investigated in cell culture and on 6-hydroxydopamine (6-OHDA)-induced Parkinson's model rats. The effects of the plant on the pathophysiology of Parkinson's disease were evaluated by biochemical and histopathological analyses; in addition, the structures of the compounds isolated from the active extracts were elucidated and the in vitro antioxidant and antiparkinsonian activities of these compounds were determined.

Results: Methanol and n-butanol extracts prepared from the aerial parts of V. canescens subsp. variegata showed significant antiparkinsonian effects both in cell culture and in a rat model. Histopathological and biochemical analyses were also parallel to in vivo experiments. As a result of the isolation studies, six flavonol glycosides were obtained from the plant, and their antioxidant capacities as well as antiparkinsonian effects were subsequently evaluated. The highest biological effect was observed in quercetin-3-O-α-l-rhamnopyranoside (quercitrin, VCB-3).

Conclusion: In the light of the studies, the antiparkinsonian effects of V. canescens subsp. variegata was evaluated. It was seen that they prevented neurodegeneration and the oxidative stress that occurred, and the most effective compounds were determined. Two new compounds named viciacoside A and B have been added to the literature as a result of this research. © 2025 Society of Chemical Industry.

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.