早产儿间歇性低氧血症事件发生前和期间膈肌活动的改变。

IF 2.3 4区 医学 Q2 PEDIATRICS
Ruud W van Leuteren, Lieke A P Arts, Fabio A Blom, Frans H de Jongh, Anton H van Kaam, G Jeroen Hutten
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引用次数: 0

摘要

目的:利用肌电图(dEMG)评估早产婴儿在呼吸暂停引起的间歇性低氧血症(IH)事件之前和期间的膈肌活动。环境:新生儿重症监护病房。方法:测定24小时心率、血氧饱和度(SpO2)和脑电图(dEMG)。对所有IH事件(导致SpO2min)的dEMG数据进行处理,并在每个事件的三个时间段(前5-1分钟,前1分钟和去饱和期间)计算最大(dEMGmax)膈肌活动。随着时间的推移,还比较了不同呼吸暂停类型之间的dEMG活动。结果:共纳入20例婴儿(胎龄27.6±1.3周)。共有591例IH事件被用于分析,其中88例(14.9%)、239例(40.4%)和264例(44.7%)分别被评为中心型、阻塞性和混合型。在实际IH前1分钟,dEMGmax和dEMGmin在中枢性事件中下降,在阻塞性事件中升高。在实际事件中,中枢性和阻塞性事件也存在差异(dEMGmin为6.1 vs 8.4µV, dEMGmax为9.4 vs 13.3µV)。结论:dEMG可以在IH事件发生前检测和表征中枢性和阻塞性呼吸暂停,这支持了呼吸暂停事件自动检测和分类的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Alterations in diaphragmatic activity preceding and during intermittent hypoxaemia events in preterm infants.

Alterations in diaphragmatic activity preceding and during intermittent hypoxaemia events in preterm infants.

Alterations in diaphragmatic activity preceding and during intermittent hypoxaemia events in preterm infants.

Alterations in diaphragmatic activity preceding and during intermittent hypoxaemia events in preterm infants.

Objective: To assess the activity of the diaphragm using electromyography (dEMG) prior and during apnoea-induced intermittent hypoxaemia (IH) events in preterm infants DESIGN: A single-centre observational study.

Setting: Neonatal intensive care unit.

Patients: Preterm infants (<32 weeks of gestation) experiencing IH events with a frequency of >1/hour METHODS: Heart rate, oxygen saturation (SpO2) and dEMG were measured for 24 hours. dEMG data were processed for all IH events resulting in a SpO2<80%. Events were scored by two reviewers as central, obstructive or mixed. Subsequently, minimum (dEMGmin) and maximum (dEMGmax) diaphragmatic activity were calculated in three time periods (5-1 min prior, 1 min prior and during the desaturation) for each event. The dEMG activity over time was also compared between the different apnoea types.

Results: 20 infants (gestational age 27.6±1.3 weeks) were included. A total of 591 IH events were used for analysis of which 88 (14.9%), 239 (40.4%) and 264 (44.7%) were scored as central, obstructive and mixed, respectively. In the 1 min before the actual IH, dEMGmax and dEMGmin dropped for central and increased for obstructive events. Central and obstructive events also differed during the actual event (dEMGmin 6.1 vs 8.4 µV and dEMGmax 9.4 vs 13.3 µV, both p<0.001 for central vs obstructive events). Mixed events did not show a distinct dEMG pattern.

Conclusion: dEMG can detect and characterise central and obstructive apnoea before the IH event occurs, which supports development of automated detection and classification of apnoea events.

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来源期刊
BMJ Paediatrics Open
BMJ Paediatrics Open Medicine-Pediatrics, Perinatology and Child Health
CiteScore
4.10
自引率
3.80%
发文量
124
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