Ondrej Bezdicek, Jiří Motýl, Tomáš Nikolai, Adéla Fendrych Mazancová, Jakub Hort, Robert Jech, Martin Vyhnálek, Hana Horáková
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引用次数: 0
摘要
阿尔茨海默病(AD)和帕金森病(PD)通常都与记忆功能障碍有关,但它们的病理生理基础不同。目前的研究旨在区分AD与PD引起的记忆障碍的具体特征。我们在“临床认知正常”的对照组(CN, n = 161)、AD (AD- amci, n = 50)和PD (PD- mci, n = 22)以及认知正常的PD (n = 18)中使用了基于记忆结合测试(MBT)的受控学习和线索回忆范式,以防止诊断决策中的循环。我们采用协方差分析(ANCOVA)和受试者工作特征分析(ROC)来确定MBT的组间差异和检测潜力。我们发现在AD-aMCI配对提示回忆条件下,组间差异较大,记忆表现较差(0.050)。MBT配对线索回忆在AD-aMCI和PD-MCI之间区分记忆损伤的检测潜力为90% (95% CI, 85-96)和91% (95% CI, 81- 99)。与PD-MCI和对照组相比,AD-aMCI中联想记忆和结合损伤最为明显。总的来说,MBT是鉴别诊断由两种最常见的神经退行性疾病引起的记忆障碍的有效工具。
Differential cued recall memory impairment in mild cognitive impairment due to Alzheimer's disease versus Parkinson's disease.
Both Alzheimer's (AD) and Parkinson's disease (PD) are often associated with memory dysfunction, but their pathophysiological underpinnings differ. The current research aimed to differentiate specific profiles of memory impairment due to AD versus PD. We used controlled learning and cued recall paradigm based on the Memory Binding Test (MBT) in 'clinically cognitively normal' controls (CN; n = 161), in patients with amnestic mild cognitive impairment due to AD (AD-aMCI; n = 50) and due to PD (PD-MCI; n = 22), and in PD with normal cognition (n = 18) as based on performance in the neuropsychological battery to prevent circularity in diagnostic decision-making. We applied analysis of covariance (ANCOVA) and Receiver Operating Characteristic (ROC) analysis to determine between-group differences and detection potential of the MBT. We found statistically large between-group differences with worse memory performance in paired cued recall conditions in AD-aMCI .050). The detection potential of MBT paired cued recall for differentiating memory impairment in AD-aMCI from CN yielded an AUC of 90% (95% CI, 85-96) and an AUC of 91% (95% CI, 81->99) between AD-aMCI and PD-MCI. Associative memory and binding impairment are most pronounced in AD-aMCI in comparison to PD-MCI and controls. Overall, the MBT is an efficient tool for the differential diagnosis of memory impairment due to the two most common neurodegenerative diseases.
期刊介绍:
The Journal of Neuropsychology publishes original contributions to scientific knowledge in neuropsychology including:
• clinical and research studies with neurological, psychiatric and psychological patient populations in all age groups
• behavioural or pharmacological treatment regimes
• cognitive experimentation and neuroimaging
• multidisciplinary approach embracing areas such as developmental psychology, neurology, psychiatry, physiology, endocrinology, pharmacology and imaging science
The following types of paper are invited:
• papers reporting original empirical investigations
• theoretical papers; provided that these are sufficiently related to empirical data
• review articles, which need not be exhaustive, but which should give an interpretation of the state of research in a given field and, where appropriate, identify its clinical implications
• brief reports and comments
• case reports
• fast-track papers (included in the issue following acceptation) reaction and rebuttals (short reactions to publications in JNP followed by an invited rebuttal of the original authors)
• special issues.