Xiaoqin Liu, Qingzhi Liang, Wei Jiang, Jianlong Zhou, Chun Liu, Ling Deng, Haoyue Feng and Rensong Yue
{"title":"姜黄素及其治疗糖尿病及其并发症的新制剂的研究进展。","authors":"Xiaoqin Liu, Qingzhi Liang, Wei Jiang, Jianlong Zhou, Chun Liu, Ling Deng, Haoyue Feng and Rensong Yue","doi":"10.1039/D5FO00988J","DOIUrl":null,"url":null,"abstract":"<p >Diabetes mellitus (DM), a growing global health crisis, drives demand for safe, effective therapies. Curcumin (CUR), a turmeric-derived polyphenol, shows promise in combating DM and its complications (such as diabetic wound healing (DWH), diabetic atherosclerosis (DA), and diabetic encephalopathy (DE)) <em>via</em> multi-target mechanisms. Despite its efficacy and low toxicity, CUR's clinical application is hindered by poor solubility and bioavailability. Recent advances in novel formulations (such as nanoparticles and liposomes) aim to overcome these limitations. This review summarizes CUR's therapeutic mechanisms, highlights cutting-edge delivery systems developed over 20 years, and identifies key challenges in translation. By bridging preclinical insights with formulation innovations, we provide a roadmap for optimizing CUR-based therapies, accelerating their clinical adoption for DM management.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" 18","pages":" 6965-6999"},"PeriodicalIF":5.4000,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Curcumin and its novel formulations for diabetes mellitus and its complications: a review\",\"authors\":\"Xiaoqin Liu, Qingzhi Liang, Wei Jiang, Jianlong Zhou, Chun Liu, Ling Deng, Haoyue Feng and Rensong Yue\",\"doi\":\"10.1039/D5FO00988J\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Diabetes mellitus (DM), a growing global health crisis, drives demand for safe, effective therapies. Curcumin (CUR), a turmeric-derived polyphenol, shows promise in combating DM and its complications (such as diabetic wound healing (DWH), diabetic atherosclerosis (DA), and diabetic encephalopathy (DE)) <em>via</em> multi-target mechanisms. Despite its efficacy and low toxicity, CUR's clinical application is hindered by poor solubility and bioavailability. Recent advances in novel formulations (such as nanoparticles and liposomes) aim to overcome these limitations. This review summarizes CUR's therapeutic mechanisms, highlights cutting-edge delivery systems developed over 20 years, and identifies key challenges in translation. By bridging preclinical insights with formulation innovations, we provide a roadmap for optimizing CUR-based therapies, accelerating their clinical adoption for DM management.</p>\",\"PeriodicalId\":77,\"journal\":{\"name\":\"Food & Function\",\"volume\":\" 18\",\"pages\":\" 6965-6999\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2025-08-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food & Function\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/fo/d5fo00988j\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food & Function","FirstCategoryId":"97","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/fo/d5fo00988j","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Curcumin and its novel formulations for diabetes mellitus and its complications: a review
Diabetes mellitus (DM), a growing global health crisis, drives demand for safe, effective therapies. Curcumin (CUR), a turmeric-derived polyphenol, shows promise in combating DM and its complications (such as diabetic wound healing (DWH), diabetic atherosclerosis (DA), and diabetic encephalopathy (DE)) via multi-target mechanisms. Despite its efficacy and low toxicity, CUR's clinical application is hindered by poor solubility and bioavailability. Recent advances in novel formulations (such as nanoparticles and liposomes) aim to overcome these limitations. This review summarizes CUR's therapeutic mechanisms, highlights cutting-edge delivery systems developed over 20 years, and identifies key challenges in translation. By bridging preclinical insights with formulation innovations, we provide a roadmap for optimizing CUR-based therapies, accelerating their clinical adoption for DM management.
期刊介绍：
Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The journal focuses on food and the functions of food in relation to health.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
