莫拉黄酮D的全合成及生物学评价。
IF 3.6
2区 生物学
Q2 CHEMISTRY, MEDICINAL
引用次数: 0
摘要
moralaflavone D(4)是一种新发现的天然二烯酰化类黄酮，具有细胞毒性活性。在此，我们报告了它的第一次全合成，仅用六个步骤完成，总收率为5.1%。该合成的主要特征包括芳基环戊烯酰化、Claisen-Schmidt缩合和分子内环化。机制研究表明，在一组癌细胞系中，4诱导G0/G1期阻滞。结果表明，4具有中等的细胞毒活性。本文章由计算机程序翻译，如有差异，请以英文原文为准。
Total Synthesis and Biological Evaluation of Moralbaflavone D.
Moralbaflavone D (4) is a newly identified natural diprenylated flavonoid demonstrating cytotoxic activity. Herein, we report its first total synthesis, accomplished in only six steps with an overall yield of 5.1%. Key features in the synthesis included aryl ring prenylation, Claisen-Schmidt condensation, and intramolecular cyclization. Mechanistic studies have shown that 4 induces a G0/G1 phase arrest in a panel of cancer cell lines. The findings indicate that 4 exhibits moderate cytotoxic activity.
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来源期刊
CiteScore
9.10
自引率
5.90%
发文量
294
审稿时长
2.3 months
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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