导致误入歧途?澳大利亚合成代谢雄激素类固醇市场中隐藏的污染物及其潜在的健康影响

IF 2.6 3区 医学 Q2 SUBSTANCE ABUSE
Alison Craven, Jason Ferris, Suzanne Nielsen, Timothy Piatkowski
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引用次数: 0

摘要

不受管制的合成代谢雄激素类固醇(AAS)市场是一个全球性的现象,其产品成分和纯度存在显著差异。本研究旨在测定在澳大利亚销售的原子吸收剂的化学成分。方法对匿名捐赠的原子吸收光谱样品进行分析。由一个独立的法医实验室使用气相色谱-质谱法、液相色谱-质谱法和电感耦合等离子体分析对样品进行化学分析,以确定有效成分、污染物和重金属,并从减少危害的角度对结果进行解释。结果28份AAS样品(注射用16份,口服10份,原料药2份)中有15份存在误标或误售现象。当考虑21个具有明确定义的预期标记剂量的样品时,其中4个样品的预期纯度偏差在±5%以内。注射制品和口服制品中共检出12种重金属,注射制品中平均浓度为0.07 ~ 62.54 μg/mL,口服制品中平均浓度为1.94 ~ 47,901 μg/g。原料粉中共检出7种金属,平均含量为23.0 μg/g,范围为0.96 ~ 51.73 μg/g。讨论与结论原子吸收光谱产品的可变性和污染性对健康构成重大威胁。实施全面的监测和检测系统至关重要。这种方法将跟踪趋势,识别污染物,并为消费者提供实时、准确的信息,以支持明智的决策和减少危害。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lead Astray? The Hidden Contaminants in Australian Anabolic–Androgenic Steroid Market and Their Potential Health Impact

Introduction

Unregulated anabolic–androgenic steroid (AAS) markets are a global phenomenon with significant variability in product composition and purity. This study aimed to determine the chemical composition of AAS sold in Australia.

Methods

This study analysed anonymously donated AAS samples. Samples were chemically analysed by an independent forensic laboratory using gas chromatography–mass spectrometry, liquid chromatography–mass spectrometry and inductively coupled plasma analysis to identify active ingredients, contaminants and heavy metals, with results interpreted in the context of harm reduction.

Results

Analysis of 28 AAS samples (16 injectable, 10 oral, 2 raw powders) revealed that 15 samples were mislabelled or mis-sold. When considering the 21 samples with clearly defined expected labelled dosages, 4 of these were within a ±5% deviation of the expected purity. Twelve heavy metals were detected in injectable and oral products, with mean concentrations ranging from 0.07 to 62.54 μg/mL in injectables and 1.94–47,901 μg/g in orals. Seven metals were identified in raw powders (mean 23.0 μg/g, range 0.96–51.73 μg/g).

Discussion and Conclusions

The variability and contamination of AAS products pose significant health risks. Implementing a comprehensive surveillance and testing system is essential. This approach would track trends, identify contaminants and provide consumers with real-time, accurate information to support informed decision-making and harm reduction.

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来源期刊
Drug and alcohol review
Drug and alcohol review SUBSTANCE ABUSE-
CiteScore
4.80
自引率
10.50%
发文量
151
期刊介绍: Drug and Alcohol Review is an international meeting ground for the views, expertise and experience of all those involved in studying alcohol, tobacco and drug problems. Contributors to the Journal examine and report on alcohol and drug use from a wide range of clinical, biomedical, epidemiological, psychological and sociological perspectives. Drug and Alcohol Review particularly encourages the submission of papers which have a harm reduction perspective. However, all philosophies will find a place in the Journal: the principal criterion for publication of papers is their quality.
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