室间隔LYVE1+巨噬细胞控制脂肪干细胞成脂潜能

IF 45.8 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-08-28 DOI:10.1126/science.adg1128

Xiaotong Yu, Yanan Hu, Hwee Ying Lim, Ziyi Li, Diego Adhemar Jaitin, Katharine Yang, Wan Ting Kong, Jiaqian Xu, David Alejandro Bejarano, Mathilde Bied, Lucie Orliaguet, Gowshika Rengasamy, Zachary Chow, Christopher Zhe Wei Lee, Josephine Lum, Jing Tian, Xiao-Meng Zhang, Honghao Liu, Shu Wen Tan, Jinmiao Chen, Peter See, Yuin-Han Loh, Benoit Malleret, Sonia Baig, M. Shabeer M. Yassin, Sue-Anne Ee Shiow Toh, Bernard Malissen, Xiujun Fu, Kenji Kabashima, Lai Guan Ng, Camille Blériot, Zhaoyuan Liu, Lingling Sheng, Dan-Ning Zheng, Junwen Qu, Nicolas Venteclef, Bing Su, Ido Amit, Andreas Schlitzer, Veronique Angeli, Florent Ginhoux, Svetoslav Chakarov

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引用次数: 0

摘要

组织巨噬细胞存在于解剖学上不同的组织下壁龛中，这决定了它们的身份和功能。在白色脂肪组织（WAT）中，我们确定了三种巨噬细胞群体，它们具有不同的定位、周转和表型。由CD209b和淋巴管内皮透明质酸受体1标记的间隔脂肪组织巨噬细胞（sATMs）寿命长，位于WAT间隔内脂肪干细胞（ASCs）附近。在这个共享的生态位中，sATMs通过转化生长因子-β1 （tgf -β1）指导ASCs向白色脂肪细胞的分化。组织内巨噬细胞中satm的消耗或TGFβ1的选择性损失，将ASC的命运转向产热脂肪细胞，增强WAT的形成并防止饮食诱导的肥胖。这些发现强调了一个离散的、解剖学上定义的巨噬细胞群体在控制ASC命运和协调脂肪组织扩张中的作用。

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Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential

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Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential

Tissue macrophages reside in anatomically distinct subtissular niches that shape their identity and function. In white adipose tissue (WAT), we identified three macrophage populations with distinct localization, turnover, and phenotypes. Septal adipose tissue macrophages (sATMs), marked by CD209b and lymphatic vessel endothelial hyaluronan receptor 1, were long-lived and positioned in close proximity to adipocyte stem cells (ASCs) within the WAT septum. Within this shared niche, sATMs instructed the differentiation of ASCs into white adipocytes through transforming growth factor–β1 (TGFβ1). Depletion of sATMs, or the selective loss of TGFβ1 within tissue-resident macrophages, redirected ASC fate toward thermogenic adipocytes, enhancing WAT beiging and protecting against diet-induced obesity. These findings highlight the role of a discrete, anatomically defined macrophage population that governs ASC fate and orchestrates adipose tissue expansion.

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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