原发性开角型青光眼外侧膝状核功能连通性改变及其与视网膜厚度的相关性：静息状态功能MRI研究

IF 3.7 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2025-08-28 DOI:10.1016/j.brainresbull.2025.111524

Xuhao Chen , Ning Wu , Shaofen Huang , Yingting Zhu , Zhidong Li , Yangjiani Li , Yue Xiao , Xinyue Shen , Ye Deng , Caibin Deng , Yehong Zhuo , Lingjing Hu , Yiqing Li

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引用次数: 0

摘要

原发性开角型青光眼（POAG）是不可逆性失明的主要原因之一。虽然青光眼的跨神经元变性在视觉通路上通过外侧膝状核（LGN），但与LGN相关的功能改变尚不清楚。本研究旨在探讨POAG患者LGN基于种子的全脑功能连接（FC）及其与视网膜厚度的相关性。方法从英国生物银行（UK Biobank）提取54例POAG患者和54例匹配的健康对照者的st1加权扫描和静息状态功能磁共振成像（rs-fMRI）。对双侧LGN进行了自动分割和FC分析。探讨视网膜厚度与FC之间的Pearson相关性。结果与对照组相比，POAG患者LGN总体积明显减小（P = 0.042）。POAG患者表现出脑区ALFF、fALFF、ReHo和度中心性值降低的模式。在POAG患者中，左侧LGN表现为右侧舌回之间的FC增加，左侧额叶中回（MFG）和左侧顶叶上小叶之间的FC减少，而左侧枕叶中回表现为右侧LGN之间的FC减少。FC在左生产厂之间的正相关和视网膜平均厚度(r = 0.292,P = 0.012),视网膜神经纤维层平均厚度(r = 0.272,P = 0.013),和神经节细胞内网状层平均厚度(r = 0.380,P = 0.001)被发现。结论POAG患者表现为LGN萎缩，静息状态功能活性降低，区域皮层中LGN的FC改变。青光眼视网膜厚度的损害与LGN的体积及其与左侧MFG的连接强度有关。这些发现为POAG患者的LGN皮质连通性改变及其与跨神经元变性的关系提供了更深入的见解。

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Altered lateral geniculate nucleus functional connectivity and its correlation with retinal thickness in primary open-angle glaucoma: A resting-state functional MRI study

Background

Primary open-angle glaucoma (POAG) is one of the predominant causes of irreversible blindness. Though the glaucomatous transneuronal degeneration pass through the lateral geniculate nucleus (LGN) in the visual pathway, the functional changes associated with the LGN remains elusive. The current study aimed to investigate the seed-based whole-brain functional connectivity (FC) of the LGN and its correlation with retinal thickness in patients with POAG.

Methods

T1-weighted scans and resting-state functional magnetic resonance imaging (rs-fMRI) were extracted from 54 patients with POAG and 54 matched healthy controls from the UK Biobank. An automatic LGN segmentation protocol and FC analysis were conducted on the bilateral LGN. The Pearson correlation between retinal thickness and FC was explored.

Results

The total LGN volume in patients with POAG was significantly decreased compared with controls (P = 0.042). The patients with POAG showed a pattern of reduced ALFF, fALFF, ReHo, and degree centrality value in brain regions. The left LGN demonstrated an increased FC between the right lingual gyrus and diminished FC with the left middle frontal gyrus (MFG) and left superior parietal lobule, whereas the left middle occipital gyrus exhibited reduced FC with the right LGN in patients with POAG. A positive correlation between the FC in the left MFG and the retinal average thickness (r = 0.292, P = 0.012), retinal nerve fiber layer average thickness (r = 0.272, P = 0.013), and ganglion cell-inner plexiform layer average thickness (r = 0.380, P = 0.001) was found.

Conclusions

Patients with POAG exhibited LGN atrophy, reduced resting-state functional activity, and altered FC with the LGN in the regional cortex. The glaucomatous impairment of retinal thickness was associated with LGN volume and its connectivity strength with the left MFG. These findings offer a deeper insight into the LGN cortical connectivity alterations and its association with transneuronal degeneration in patients with POAG.

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.