Mateusz Bożejko , Brygida Knysz , Anna Czernicka , Ignacy Tarski , Aleksandra Szymczak , Małgorzata Małodobra-Mazur
{"title":"HIV感染与加速表观遗传衰老有关:系统综述","authors":"Mateusz Bożejko , Brygida Knysz , Anna Czernicka , Ignacy Tarski , Aleksandra Szymczak , Małgorzata Małodobra-Mazur","doi":"10.1016/j.arr.2025.102884","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>We conducted a systematic review of studies comparing the intensity of epigenetic ageing in people living with human immunodeficiency virus (HIV) and uninfected individuals. We included studies that quantitatively examined the intensity of age-related epigenetic changes in both groups.</div></div><div><h3>Results</h3><div>We identified 25 studies meeting the inclusion criteria. The results of the vast majority (22 out of 25) of the studies included in the review indicate the presence of accelerated epigenetic ageing in people living with HIV compared to uninfected individuals. Most studies reported evidence of epigenetic age acceleration in people living with HIV, both among those not receiving antiretroviral therapy (ART) and those who were on ART treatment. However, the studies included in the review were conducted mostly on relatively small groups and using different methods. While several studies have carefully addressed confounding variables, others did not report adjustments for factors such as BMI, diabetes, HBV and HCV co-infections, or lifestyle influences, which may be especially relevant for interpreting second-generation epigenetic clocks such as GrimAge and PhenoAge.</div></div><div><h3>Conclusions</h3><div>We believe that the results of our review indicate accelerated epigenetic ageing in people living with HIV compared to uninfected individuals. There is a need for further research, which will analyse material from different tissues and take into account a number of biomarkers and the mentioned confounding factors. Studies considering the impact of individual classes of antiretroviral drugs, the age of the patient at the time of HIV diagnosis, and the timeliness of diagnosis on epigenetic ageing are particularly needed.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"112 ","pages":"Article 102884"},"PeriodicalIF":12.4000,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"HIV infection is associated with accelerated epigenetic ageing: A systematic review\",\"authors\":\"Mateusz Bożejko , Brygida Knysz , Anna Czernicka , Ignacy Tarski , Aleksandra Szymczak , Małgorzata Małodobra-Mazur\",\"doi\":\"10.1016/j.arr.2025.102884\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>We conducted a systematic review of studies comparing the intensity of epigenetic ageing in people living with human immunodeficiency virus (HIV) and uninfected individuals. We included studies that quantitatively examined the intensity of age-related epigenetic changes in both groups.</div></div><div><h3>Results</h3><div>We identified 25 studies meeting the inclusion criteria. The results of the vast majority (22 out of 25) of the studies included in the review indicate the presence of accelerated epigenetic ageing in people living with HIV compared to uninfected individuals. Most studies reported evidence of epigenetic age acceleration in people living with HIV, both among those not receiving antiretroviral therapy (ART) and those who were on ART treatment. However, the studies included in the review were conducted mostly on relatively small groups and using different methods. While several studies have carefully addressed confounding variables, others did not report adjustments for factors such as BMI, diabetes, HBV and HCV co-infections, or lifestyle influences, which may be especially relevant for interpreting second-generation epigenetic clocks such as GrimAge and PhenoAge.</div></div><div><h3>Conclusions</h3><div>We believe that the results of our review indicate accelerated epigenetic ageing in people living with HIV compared to uninfected individuals. There is a need for further research, which will analyse material from different tissues and take into account a number of biomarkers and the mentioned confounding factors. Studies considering the impact of individual classes of antiretroviral drugs, the age of the patient at the time of HIV diagnosis, and the timeliness of diagnosis on epigenetic ageing are particularly needed.</div></div>\",\"PeriodicalId\":55545,\"journal\":{\"name\":\"Ageing Research Reviews\",\"volume\":\"112 \",\"pages\":\"Article 102884\"},\"PeriodicalIF\":12.4000,\"publicationDate\":\"2025-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ageing Research Reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1568163725002302\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ageing Research Reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1568163725002302","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
HIV infection is associated with accelerated epigenetic ageing: A systematic review
Purpose
We conducted a systematic review of studies comparing the intensity of epigenetic ageing in people living with human immunodeficiency virus (HIV) and uninfected individuals. We included studies that quantitatively examined the intensity of age-related epigenetic changes in both groups.
Results
We identified 25 studies meeting the inclusion criteria. The results of the vast majority (22 out of 25) of the studies included in the review indicate the presence of accelerated epigenetic ageing in people living with HIV compared to uninfected individuals. Most studies reported evidence of epigenetic age acceleration in people living with HIV, both among those not receiving antiretroviral therapy (ART) and those who were on ART treatment. However, the studies included in the review were conducted mostly on relatively small groups and using different methods. While several studies have carefully addressed confounding variables, others did not report adjustments for factors such as BMI, diabetes, HBV and HCV co-infections, or lifestyle influences, which may be especially relevant for interpreting second-generation epigenetic clocks such as GrimAge and PhenoAge.
Conclusions
We believe that the results of our review indicate accelerated epigenetic ageing in people living with HIV compared to uninfected individuals. There is a need for further research, which will analyse material from different tissues and take into account a number of biomarkers and the mentioned confounding factors. Studies considering the impact of individual classes of antiretroviral drugs, the age of the patient at the time of HIV diagnosis, and the timeliness of diagnosis on epigenetic ageing are particularly needed.
期刊介绍:
With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends.
ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research.
The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.