从时钟到时钟：发现衰老和年龄相关疾病的治疗靶点

IF 12.4 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-08-12 DOI:10.1016/j.arr.2025.102871

Jianjiu Chen , Geoffrey Ho Duen Leung , Howell Leung , Alina Ustiugova , Anastasia Shneyderman , Mike Korzinkin , David Gennert , Frank W. Pun , Alex Aliper , Feng Ren , Alex Zhavoronkov

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引用次数: 0

摘要

全球人口老龄化需要发展新的治疗方法，通过预防和治疗与年龄有关的疾病来提高生活质量。在这篇综述中，我们首先讨论了衰老和年龄相关疾病的双重目标识别策略的优势，并评估了衰老的特征，作为识别这种双重目标的方法。由于衰老研究与机器学习（ML）和其他人工智能（AI）模型的融合，衰老时钟最初是作为衰老生物标志物开发的，但它在识别治疗靶点方面的价值也越来越得到认可。在最近发表的衰老时钟的基础上，我们通过识别时钟相关基因，重建了已知药物靶标的很大一部分，强调了这些时钟在靶标识别方面的潜力。最后，我们讨论了衰老时钟在药物开发中的其他应用，如人口分层和疾病和治疗监测。随着多组学数据的日益可用性以及ML和AI的快速发展，我们预计衰老时钟研究将加速进展，为创新治疗方法铺平道路，以满足全球老龄化人口的医疗保健需求。

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From clock to clock: Therapeutic target discovery for aging and age-related diseases

The aging population worldwide necessitates the development of novel therapeutics that enhance the quality of life by preventing and treating age-related diseases. In this review, we first discuss the advantages of a dual-purpose target identification strategy for aging and age-related diseases, with assessment of the hallmarks of aging as an approach to identify such dual-purpose targets. Resulting from a convergence of aging research with machine learning (ML) and other artificial intelligence (AI) models, aging clocks were initially developed as aging biomarkers, but its value in identifying therapeutic targets is also increasingly recognized. Building on recently published aging clocks, we reestablish a significant proportion of known drug targets by identifying clock-associated genes, highlighting the potential of these clocks for target identification. Lastly, we discuss other applications of aging clocks in drug development such as population stratification and disease and treatment monitoring. With the growing availability of multi-omics data and rapid advancements in ML and AI, we anticipate accelerated progress in aging clock research, paving the way for innovative treatments to meet the healthcare needs of a global aging population.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.