儿童和青少年抗SARS-CoV-2抗体:一项为期一年的纵向研究

IF 2.3 4区 医学 Q2 PEDIATRICS
Luciana de Freitas Velloso Monte, Ana Luiza Rosa Diniz, Cristiane Feitosa Salviano, Agenor de Castro Moreira Dos Santos Júnior, Ricardo Camargo, Isis Maria Quezado Magalhães, Elisa de Carvalho, Valdenize Tiziani
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引用次数: 0

摘要

背景:对SARS-CoV-2的体液反应尚未完全了解,特别是在儿童中。这项研究为未接种疫苗并自然感染SARS-CoV-2原型菌株的儿科患者(包括无症状或先前存在慢性和罕见疾病的患者)的适应性免疫持久性提供了有价值的见解。本研究旨在分析在COVID-19大流行开始时入住三级儿科医院的0-18岁患者在感染期间和1年随访期间对SARS-CoV-2的抗体反应。方法:这是一项描述性的、前瞻性的1年队列研究,研究对象是2020年7月至10月因不同原因住院的SARS-CoV-2感染儿童和青少年。在SARS-CoV-2感染期间和随后一年收集临床和血清学数据(总抗体池)。结果:研究期间共纳入122例确诊的SARS-CoV-2感染患者。大多数患者(85%)在1年的随访中至少有一项血清学评估和反应性,即使是那些无症状感染或免疫抑制的患者。平均抗体滴度水平在首次感染SARS-CoV-2后约60天达到最大值。到1年随访结束时,69名被评估个体中仍有72.46%可检测到血清抗体。有合并症和/或免疫抑制条件的患者在这一年的中位滴度水平较低。有严重临床表现的受试者在1年时间点评估时抗体水平较高。结论:本研究表明,大多数受试者在1年的随访中出现了针对SARS-CoV-2的抗体应答,即使他们有无症状感染或合并症,包括免疫抑制患者。抗体反应的强度和持续时间存在差异,有合并症的患者抗体反应较低,有严重COVID-19临床表现的患者抗体反应时间更长,持续时间更长。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antibodies against SARS-CoV-2 in children and adolescents: a one-year longitudinal study.

Background: The humoral response to SARS-CoV-2 is not fully understood, especially in children. This study provides valuable insights into the durability of adaptive immunity in paediatric patients who were unvaccinated and naturally infected with the prototype strain of SARS-CoV-2, including those who were asymptomatic or had pre-existing chronic and rare disorders. This study aimed to analyse the antibody response to SARS-CoV-2 during infection and over a 1-year follow-up period in patients aged 0-18 years who were admitted to a tertiary paediatric hospital at the onset of the COVID-19 pandemic.

Methods: This is a descriptive, prospective 1-year cohort study carried out in children and adolescents hospitalised for different reasons from July to October 2020 who presented with SARS-CoV-2 infection. Clinical and serological data (total antibody pool) were collected during SARS-CoV-2 infection and throughout the subsequent year.

Results: During the study period, 122 patients with confirmed SARS-CoV-2 infection were included. Most patients (85%) had at least one serology assessed and reactive throughout 1-year follow-up, even those with asymptomatic infection or immunosuppressive conditions. The mean antibody titre levels reached their maximum value about 60 days after the initial SARS-CoV-2 infection. By the end of the 1-year follow-up, 72.46% of the 69 assessed individuals still had detectable serum antibodies. Patients with comorbidities and/or immunosuppression conditions had lower median titre levels over the year. Subjects with severe clinical presentation of COVID-19 had higher levels of antibody values at the 1-year time point assessment.

Conclusions: This study demonstrated that most subjects presented antibody response against SARS-CoV-2 over 1 year of follow-up, even if they had asymptomatic infection or comorbidities, including patients with immunosuppression. There was a difference in the magnitude and duration of antibody response, lower in patients with comorbidities and longer and higher in subjects who had severe COVID-19 clinical presentation.

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来源期刊
BMJ Paediatrics Open
BMJ Paediatrics Open Medicine-Pediatrics, Perinatology and Child Health
CiteScore
4.10
自引率
3.80%
发文量
124
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