慢性内脏痛中的脊髓星形胶质细胞

IF 2.3 4区 医学 Q2 DEVELOPMENTAL BIOLOGY
Wenfeng Li, Lili Zhang, Shaozong Chen
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引用次数: 0

摘要

慢性内脏疼痛是功能性胃肠疾病的主要症状,影响到多达20%的人口。它包括周围神经系统的外周敏化和中枢神经系统的中枢敏化。近年来,相关研究已从神经元扩展到神经胶质细胞,特别是脊髓的星形胶质细胞被激活,偶联增强,对疼痛介质表现出更高的敏感性。本文就脊髓星形胶质细胞在不同动物内脏疼痛模型中的作用机制作一综述。脊髓星形胶质细胞在内脏痛发病机制中的作用也正在出现,星形胶质细胞很可能成为未来慢性内脏痛治疗的靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Spinal Astrocytes in Chronic Visceral Pain

Chronic visceral pain is the primary symptom of functional gastrointestinal disorders, affecting up to 20% of the population. It involves peripheral sensitization in the peripheral nervous system and central sensitization in the central nervous system (CNS). In recent years, related research has extended from neurons to glial cells, particularly astrocytes in the spinal cord, which become activated, exhibit enhanced coupling, and show higher sensitivity to pain mediators. This review discusses the mechanisms of spinal astrocytes in different animal models of visceral pain. A role of spinal astrocytes in the pathogenesis of visceral pain is also emerging, and astrocytes are likely to be a target for the future therapies of chronic visceral pain.

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来源期刊
Developmental Neurobiology
Developmental Neurobiology 生物-发育生物学
CiteScore
6.50
自引率
0.00%
发文量
45
审稿时长
4-8 weeks
期刊介绍: Developmental Neurobiology (previously the Journal of Neurobiology ) publishes original research articles on development, regeneration, repair and plasticity of the nervous system and on the ontogeny of behavior. High quality contributions in these areas are solicited, with an emphasis on experimental as opposed to purely descriptive work. The Journal also will consider manuscripts reporting novel approaches and techniques for the study of the development of the nervous system as well as occasional special issues on topics of significant current interest. We welcome suggestions on possible topics from our readers.
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