肿瘤治疗场技术在乳腺癌治疗中的研究与优化：模拟研究。

IF 1.6 4区医学 Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-08-08 DOI:10.1080/10255842.2025.2542939

Shimaa Mahdy, Haitham S Mohammed, Omnia Hamdy

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引用次数: 0

摘要

肿瘤治疗电场（TTFields）使用交变电场（1-3 V/cm, 100-300 kHz）破坏肿瘤细胞分裂。本研究利用基于comsol的乳腺不规则肿瘤不同腺体位置和体积模型，探讨了TTFields在乳腺癌中的作用。对多种电极结构进行了分析。使用生物热方程评估皮肤温度随时间的变化。结果表明，在12个电极设置下施加±20 V可在保持安全皮肤温度的情况下有效靶向肿瘤。该有限元分析突出了TTFields在乳腺癌治疗中的潜力，并为未来临床应用中优化治疗参数提供了基础。

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Investigation and optimization of tumor-treating fields technique for breast cancer treatment: a simulation study.

Tumor-treating fields (TTFields) use alternating electric fields (1-3 V/cm, 100-300 kHz) to disrupt tumor cell division. This study explored TTFields for breast cancer using a COMSOL-based model of a breast with irregular tumors in various glandular positions and volumes. Multiple electrode configurations were analyzed. Skin temperature over time was evaluated using the bioheat equation. Results showed that applying ±20 V with a 12-electrode setup delivered effective tumor targeting while maintaining safe skin temperatures. This finite-element analysis highlights TTFields' potential for breast cancer therapy and provides a foundation for optimizing treatment parameters in future clinical applications.

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来源期刊

Computer Methods in Biomechanics and Biomedical Engineering 工程技术-工程：生物医学

CiteScore

4.10

自引率

6.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： The primary aims of Computer Methods in Biomechanics and Biomedical Engineering are to provide a means of communicating the advances being made in the areas of biomechanics and biomedical engineering and to stimulate interest in the continually emerging computer based technologies which are being applied in these multidisciplinary subjects. Computer Methods in Biomechanics and Biomedical Engineering will also provide a focus for the importance of integrating the disciplines of engineering with medical technology and clinical expertise. Such integration will have a major impact on health care in the future.