Stefania Guida, Margherita Tamburelli, Antonio Podo-Brunetti, Franco Rongioletti
{"title":"扁平苔藓与丙型肝炎相关,但与乙型肝炎无关:一项以意大利数据为重点的系统综述和荟萃分析","authors":"Stefania Guida, Margherita Tamburelli, Antonio Podo-Brunetti, Franco Rongioletti","doi":"10.23736/S2784-8671.25.08282-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Several studies have explored the potential association between lichen planus (LP) and chronic hepatitis C (HCV) and hepatitis B virus (HBV) related, yielding conflicting results.</p><p><strong>Objective: </strong>To determine whether there is an association between these two entities, through a systemic review and meta-analysis.</p><p><strong>Methods: </strong>Bibliographic searches were conducted using PubMed and Scopus databases. Data obtained from papers included in the systematic review were put into a quantitative meta-analysis, carried out with SPSS software version (29.0.2.0).</p><p><strong>Results: </strong>Out of the initial pool of 834 studies, 45 studies met the inclusion criteria for meta-analysis. The odds ratio (OR) for HCV-seropositivity in LP patients was 4.55 (95% CI, 3.08-6.74), with higher ORs observed in Mediterranean basin countries (OR: 5.41, 95% CI: 3.16-9.29). In Italy, the OR was 4.42 (95% CI, 1.99-9.81). A regional variation was noted within Italy, with a higher OR in northern Italy-compared to southern Italy. Similar associations were found in Asian countries, with an OR of 4.49 (95% CI, 2.94-6.88). However, in northern Europe, the pooled OR was 0.733 (95% CI, 0.15-3.66), indicating no statistically significant association. When considering subjects with HCV infection, the presence of LP showed a pooled OR of 3.22 (95% CI, 1-10.34). Regarding HBV infection, the OR was 1.51 (95% CI, 1.15-1.97), with no differences and was similar when analyzing different subgroups.</p><p><strong>Conclusions: </strong>Our study indicates a moderate to high risk for HCV in patients with LP, according to geographic region, while the risk remains uncertain for HBV with respective ORs of 4.55 (95% CI, 3.08-6.74) and 1.51 (95% CI, 1.15-1.97). It seems reasonable to test the sera of patients affected by LP for anti-HCV antibodies, while the necessity of testing for HBV remains more uncertain.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lichen planus is associated with hepatitis C but not with hepatitis B virus: a systematic review and meta-analysis with a focus on Italian data.\",\"authors\":\"Stefania Guida, Margherita Tamburelli, Antonio Podo-Brunetti, Franco Rongioletti\",\"doi\":\"10.23736/S2784-8671.25.08282-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Several studies have explored the potential association between lichen planus (LP) and chronic hepatitis C (HCV) and hepatitis B virus (HBV) related, yielding conflicting results.</p><p><strong>Objective: </strong>To determine whether there is an association between these two entities, through a systemic review and meta-analysis.</p><p><strong>Methods: </strong>Bibliographic searches were conducted using PubMed and Scopus databases. Data obtained from papers included in the systematic review were put into a quantitative meta-analysis, carried out with SPSS software version (29.0.2.0).</p><p><strong>Results: </strong>Out of the initial pool of 834 studies, 45 studies met the inclusion criteria for meta-analysis. The odds ratio (OR) for HCV-seropositivity in LP patients was 4.55 (95% CI, 3.08-6.74), with higher ORs observed in Mediterranean basin countries (OR: 5.41, 95% CI: 3.16-9.29). In Italy, the OR was 4.42 (95% CI, 1.99-9.81). A regional variation was noted within Italy, with a higher OR in northern Italy-compared to southern Italy. Similar associations were found in Asian countries, with an OR of 4.49 (95% CI, 2.94-6.88). However, in northern Europe, the pooled OR was 0.733 (95% CI, 0.15-3.66), indicating no statistically significant association. When considering subjects with HCV infection, the presence of LP showed a pooled OR of 3.22 (95% CI, 1-10.34). Regarding HBV infection, the OR was 1.51 (95% CI, 1.15-1.97), with no differences and was similar when analyzing different subgroups.</p><p><strong>Conclusions: </strong>Our study indicates a moderate to high risk for HCV in patients with LP, according to geographic region, while the risk remains uncertain for HBV with respective ORs of 4.55 (95% CI, 3.08-6.74) and 1.51 (95% CI, 1.15-1.97). It seems reasonable to test the sera of patients affected by LP for anti-HCV antibodies, while the necessity of testing for HBV remains more uncertain.</p>\",\"PeriodicalId\":14526,\"journal\":{\"name\":\"Italian Journal of Dermatology and Venereology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-08-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Italian Journal of Dermatology and Venereology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.23736/S2784-8671.25.08282-9\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Italian Journal of Dermatology and Venereology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.23736/S2784-8671.25.08282-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Lichen planus is associated with hepatitis C but not with hepatitis B virus: a systematic review and meta-analysis with a focus on Italian data.
Background: Several studies have explored the potential association between lichen planus (LP) and chronic hepatitis C (HCV) and hepatitis B virus (HBV) related, yielding conflicting results.
Objective: To determine whether there is an association between these two entities, through a systemic review and meta-analysis.
Methods: Bibliographic searches were conducted using PubMed and Scopus databases. Data obtained from papers included in the systematic review were put into a quantitative meta-analysis, carried out with SPSS software version (29.0.2.0).
Results: Out of the initial pool of 834 studies, 45 studies met the inclusion criteria for meta-analysis. The odds ratio (OR) for HCV-seropositivity in LP patients was 4.55 (95% CI, 3.08-6.74), with higher ORs observed in Mediterranean basin countries (OR: 5.41, 95% CI: 3.16-9.29). In Italy, the OR was 4.42 (95% CI, 1.99-9.81). A regional variation was noted within Italy, with a higher OR in northern Italy-compared to southern Italy. Similar associations were found in Asian countries, with an OR of 4.49 (95% CI, 2.94-6.88). However, in northern Europe, the pooled OR was 0.733 (95% CI, 0.15-3.66), indicating no statistically significant association. When considering subjects with HCV infection, the presence of LP showed a pooled OR of 3.22 (95% CI, 1-10.34). Regarding HBV infection, the OR was 1.51 (95% CI, 1.15-1.97), with no differences and was similar when analyzing different subgroups.
Conclusions: Our study indicates a moderate to high risk for HCV in patients with LP, according to geographic region, while the risk remains uncertain for HBV with respective ORs of 4.55 (95% CI, 3.08-6.74) and 1.51 (95% CI, 1.15-1.97). It seems reasonable to test the sera of patients affected by LP for anti-HCV antibodies, while the necessity of testing for HBV remains more uncertain.