扁平苔藓与丙型肝炎相关,但与乙型肝炎无关:一项以意大利数据为重点的系统综述和荟萃分析

IF 2.6 4区 医学 Q3 DERMATOLOGY
Stefania Guida, Margherita Tamburelli, Antonio Podo-Brunetti, Franco Rongioletti
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引用次数: 0

摘要

背景:一些研究已经探讨了扁平苔藓(LP)与慢性丙型肝炎(HCV)和乙型肝炎病毒(HBV)相关的潜在关联,但结果相互矛盾。目的:通过系统回顾和荟萃分析,确定这两个实体之间是否存在关联。方法:使用PubMed和Scopus数据库进行文献检索。从纳入系统评价的论文中获得的数据进行定量meta分析,使用SPSS软件版本(29.0.2.0)进行。结果:在最初的834项研究中,有45项研究符合meta分析的纳入标准。LP患者hcv血清阳性的比值比(OR)为4.55 (95% CI, 3.08-6.74),地中海盆地国家的比值比更高(OR: 5.41, 95% CI: 3.16-9.29)。在意大利,OR为4.42 (95% CI, 1.99-9.81)。意大利内部存在区域差异,与意大利南部相比,意大利北部的OR更高。在亚洲国家也发现了类似的关联,OR为4.49 (95% CI, 2.94-6.88)。然而,在北欧,合并OR为0.733 (95% CI, 0.15-3.66),表明无统计学意义的关联。当考虑HCV感染的受试者时,LP的存在显示合并OR为3.22 (95% CI, 1-10.34)。对于HBV感染,OR为1.51 (95% CI为1.15-1.97),在分析不同亚组时无差异且相似。结论:我们的研究表明,根据地理区域,LP患者的HCV风险为中至高,而HBV的风险仍不确定,各自的or为4.55 (95% CI, 3.08-6.74)和1.51 (95% CI, 1.15-1.97)。在LP患者的血清中检测抗hcv抗体似乎是合理的,而检测HBV的必要性仍不确定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lichen planus is associated with hepatitis C but not with hepatitis B virus: a systematic review and meta-analysis with a focus on Italian data.

Background: Several studies have explored the potential association between lichen planus (LP) and chronic hepatitis C (HCV) and hepatitis B virus (HBV) related, yielding conflicting results.

Objective: To determine whether there is an association between these two entities, through a systemic review and meta-analysis.

Methods: Bibliographic searches were conducted using PubMed and Scopus databases. Data obtained from papers included in the systematic review were put into a quantitative meta-analysis, carried out with SPSS software version (29.0.2.0).

Results: Out of the initial pool of 834 studies, 45 studies met the inclusion criteria for meta-analysis. The odds ratio (OR) for HCV-seropositivity in LP patients was 4.55 (95% CI, 3.08-6.74), with higher ORs observed in Mediterranean basin countries (OR: 5.41, 95% CI: 3.16-9.29). In Italy, the OR was 4.42 (95% CI, 1.99-9.81). A regional variation was noted within Italy, with a higher OR in northern Italy-compared to southern Italy. Similar associations were found in Asian countries, with an OR of 4.49 (95% CI, 2.94-6.88). However, in northern Europe, the pooled OR was 0.733 (95% CI, 0.15-3.66), indicating no statistically significant association. When considering subjects with HCV infection, the presence of LP showed a pooled OR of 3.22 (95% CI, 1-10.34). Regarding HBV infection, the OR was 1.51 (95% CI, 1.15-1.97), with no differences and was similar when analyzing different subgroups.

Conclusions: Our study indicates a moderate to high risk for HCV in patients with LP, according to geographic region, while the risk remains uncertain for HBV with respective ORs of 4.55 (95% CI, 3.08-6.74) and 1.51 (95% CI, 1.15-1.97). It seems reasonable to test the sera of patients affected by LP for anti-HCV antibodies, while the necessity of testing for HBV remains more uncertain.

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