高强度聚焦超声照射下血管内声压的数值分析。

IF 1.6 4区医学 Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-08-04 DOI:10.1080/10255842.2025.2541896

Jonghyok Ri, Na Pang, Lisheng Xu, Ning Ji, Xiangji Yue, Insong Kim, Li Shen, Dingchang Zheng

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引用次数: 0

摘要

本研究探讨了高强度聚焦超声（HIFU）用于超声溶栓（STL）的血管内声压分布。模拟组织模型（皮肤、脂肪、肌肉、血液），使用Westervelt方程计算压力。结果表明，峰值压力随频率（0.5-2 MHz）的增加而增加，随功率、频率和容器深度（10-30 mm）的增加而衰减加剧。频率高于1.1 MHz时，受皮肤（1-5毫米）和脂肪（2-7毫米）厚度的影响，衰减更大。在1.1 MHz以下，一致的HIFU功率在患者中产生相似的临床结果，有助于STL治疗的优化。

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Numerical analysis of the acoustic pressure inside blood vessel with exposure to high-intensity focused ultrasound.

This study investigates acoustic pressure distribution in blood vessels under high-intensity focused ultrasound (HIFU) for sonothrombolysis (STL). A tissue-mimicking phantom (skin, fat, muscle, blood) was modeled, and pressure was calculated using the Westervelt equation. Results show peak pressure increases with frequency (0.5-2 MHz), while attenuation intensifies with higher power, frequency, and vessel depth (10-30 mm). Frequencies above 1.1 MHz caused greater attenuation, influenced by skin (1-5 mm) and fat (2-7 mm) thicknesses. Below 1.1 MHz, consistent HIFU power yields similar clinical outcomes across patients, aiding STL treatment optimization.

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来源期刊

Computer Methods in Biomechanics and Biomedical Engineering 工程技术-工程：生物医学

CiteScore

4.10

自引率

6.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： The primary aims of Computer Methods in Biomechanics and Biomedical Engineering are to provide a means of communicating the advances being made in the areas of biomechanics and biomedical engineering and to stimulate interest in the continually emerging computer based technologies which are being applied in these multidisciplinary subjects. Computer Methods in Biomechanics and Biomedical Engineering will also provide a focus for the importance of integrating the disciplines of engineering with medical technology and clinical expertise. Such integration will have a major impact on health care in the future.