黄精多糖与PCC1协同抗衰老的新型蛋黄壳纳米颗粒递送体系

IF 8 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Research International Pub Date : 2025-08-05 DOI:10.1016/j.foodres.2025.117188

Jingjing Wen , Jingjing Liu , Yumei Nie , Pan Wang , Yitian Shao , Yiming Zhang , Ruixue Sun , Jinping Si

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引用次数: 0

摘要

原花青素C1 （PCC1）的活性受到肠道靶向性差的限制，而传统的给药系统通常忽略了肠壁材料的佐剂活性。本研究旨在探讨黄精多糖（PSP）作为具有协同效应的输送系统壁材的潜力。以赖氨酸为交联剂制备了新型PCC1蛋黄壳纳米颗粒载药体系（PCC1- p /L NPs），载药效率为93.57%。分子对接分析表明PSP通过氢键和疏水相互作用与PCC1和赖氨酸相互作用。我们进一步评估了PCC1-P/L NPs的靶向递送效率和协同效应。使肠内PCC1浓度显著升高2倍。此外，PCC1- p /L NPs具有协同抗衰老作用，可使果蝇的最大寿命延长30.8%，明显超过PCC1或PSP单独使用的效果。此外，该递送系统有效地抑制了pH 3+和esg +细胞的积累，并保持了肠道的完整性。本研究强调了PSP作为一种多功能墙体材料，为抗衰老提供了新的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A novel yolk-shell nanoparticles delivery system based on Polygonatum polysaccharides and PCC1 for synergistic anti-aging

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A novel yolk-shell nanoparticles delivery system based on Polygonatum polysaccharides and PCC1 for synergistic anti-aging

The activity of procyanidin C1 (PCC1) is limited by poor intestinal targeting, while traditional delivery systems typically neglect the adjuvant activity of the wall material. This study aimed to explore the potential of Polygonatum polysaccharides (PSP) as wall materials for delivery systems with synergistic effects. A novel PCC1 yolk-shell nanoparticles delivery system (PCC1-P/L NPs) were fabricated using lysine as a cross-linking agent, achieving a drug loading efficiency of 93.57 %. Molecular docking analysis revealed that PSP interacted with PCC1 and lysine through hydrogen bonds and hydrophobic interactions. We further evaluated the targeted delivery efficiency and synergistic effect of PCC1-P/L NPs. It significantly increased the PCC1 concentrations in the intestine by twofold. Furthermore, PCC1-P/L NPs exerted a synergistic anti-aging effect, extending the maximum lifespan of Drosophila by 30.8 %, which significantly exceeded the effect of PCC1 or PSP alone. Moreover, the delivery system potently suppressed the accumulation of pH 3+ and esg + cells and preserved gut integrity. This study highlights PSP as a multifunctional wall material and offers a new strategy for anti-aging.

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来源期刊

Food Research International 工程技术-食品科技

CiteScore

12.50

自引率

7.40%

发文量

1183

审稿时长

79 days

期刊介绍： Food Research International serves as a rapid dissemination platform for significant and impactful research in food science, technology, engineering, and nutrition. The journal focuses on publishing novel, high-quality, and high-impact review papers, original research papers, and letters to the editors across various disciplines in the science and technology of food. Additionally, it follows a policy of publishing special issues on topical and emergent subjects in food research or related areas. Selected, peer-reviewed papers from scientific meetings, workshops, and conferences on the science, technology, and engineering of foods are also featured in special issues.