外周电刺激治疗勃起功能障碍的应用:系统回顾和荟萃分析。

IF 3.4 2区 医学 Q1 UROLOGY & NEPHROLOGY
Fateme Tahmasbi, Alireza Rahimi-Mamaghani, Farzin Soleimanzadeh, Hanieh Salehi-Pourmehr, Mohsen Mohammad-Rahimi
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引用次数: 0

摘要

简介:勃起功能障碍(ED)是一种常见的衰弱性疾病,对生活质量有重大影响。外周电刺激(PES)已成为ED的潜在替代疗法,因为它旨在改善阴茎血流动力学和神经肌肉功能。然而,PES治疗ED有效性的临床证据尚不清楚。目的:对PES治疗成年男性ED的疗效进行综合系统评价。方法:采用相关关键词检索自成立至2024年4月的PubMed、Embase、Scopus、Web of Science、谷歌Scholar。研究评估使用任何形式的PES管理ED在成年男性患者纳入。两名独立审稿人筛选标题和摘要,检索全文文章,并使用标准化表格提取数据。使用适当的乔安娜布里格斯研究所(JBI)检查表评估方法学质量。采用RevMan 5.4.1软件进行meta分析。结果:1998 - 2024年共发表13项研究[6项随机对照试验(RCTs)和7项准实验研究]符合纳入标准。研究报告使用不同的PES技术,包括经皮神经电刺激(TENS)、经皮神经电刺激(PENS)、功能性电刺激(FES)和经肛门盆丛电刺激(TPPS)。6项研究符合meta分析。第一个分析,评估PES治疗ED前后的结果,显示国际勃起功能指数(IIEF)评分的平均差异为3.09 (95% CI: -2.19至8.38;I2 = 99%),表明PES后勃起功能无显著改善。第二次分析,将干预组与对照组进行比较,显示显着更高的平均差异为6.27 (95% CI: 4.30至8.27;I2 = 79%),表明与对照组相比,PES对勃起功能有积极作用,尽管观察到中度异质性。所有的研究都是低到中等质量的,证据的确定性很弱。结论:有限和低质量的研究表明PES治疗ED的潜在益处。然而,目前的证据不足,不能支持常规给药。建立PES优化还需要更多高质量的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Application of peripheral electrical stimulation for treatment of erectile dysfunction: a systematic review and meta-analysis.

Introduction: Erectile dysfunction (ED) is a common and debilitating condition that can have significant impacts on quality of life. Peripheral electrical stimulation (PES) has emerged as a potential alternative therapy for ED, as it aims to improve penile hemodynamics and neuromuscular function. However, the clinical evidence on the effectiveness of PES for managing ED remains unclear.

Objective: To conduct a comprehensive systematic review evaluating the effectiveness of PES for the management of ED in adult male patients.

Methods: PubMed, Embase, Scopus, Web of Science, and Google Scholar were searched from inception to April 2024 using relevant keywords. Studies evaluating the use of any form of PES for the management of ED in adult male patients were included. Two independent reviewers screened titles and abstracts, retrieved full-text articles, and extracted data using a standardized form. Methodological quality was assessed using the appropriate Joanna Briggs Institute (JBI) checklists. A meta-analysis was conducted using RevMan 5.4.1 software.

Results: A total of 13 studies [6 randomized controlled trials (RCTs) and 7 quasi-experimental studies], published from 1998 to 2024, satisfied the inclusion criteria. Studies reported on using different PES techniques, including transcutaneous electrical nerve stimulation (TENS), percutaneous electrical nerve stimulation (PENS), functional electrical stimulation (FES), and transanal pelvic plexus stimulation (TPPS). Six studies were eligible for the meta-analysis. The first analysis, evaluating the before-and-after results of PES on ED, showed a mean difference in International Index of Erectile Function (IIEF) scores of 3.09 (95% CI: -2.19 to 8.38; I2 = 99%), indicating a non-significant improvement in erectile function following PES. The second analysis, comparing the intervention group with a control group, showed a significantly higher mean difference of 6.27 (95% CI: 4.30 to 8.27; I2 = 79%), suggesting a positive effect of PES on erectile function compared to the control group, though moderate heterogeneity was observed. All the studies were of low to moderate quality, and the certainty of the evidence was weak.

Conclusion: Limited and low-quality research suggested the potential benefits of PES for treating ED. However, the current evidence is weak and cannot support routine administration. More high-quality research is needed to establish PES optimization.

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来源期刊
Sexual medicine reviews
Sexual medicine reviews UROLOGY & NEPHROLOGY-
CiteScore
7.60
自引率
8.30%
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5
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