保留射血分数的心力衰竭患者动态脑网络的重构：连接神经血管耦合和心功能障碍

IF 3.7 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2025-08-04 DOI:10.1016/j.brainresbull.2025.111500

Xiulin Liang, Qinghua Zhang, Chuanlong Zhang, Jingjing Liu, Pengcheng Sang, Qing Mao, Lei Wang

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引用次数: 0

摘要

目的探讨保留射血分数（HFpEF）心力衰竭患者静态和动态网络拓扑特性的变化。方法对41例HFpEF患者和39例健康人进行功能磁共振成像（fMRI）检查。结果(1)HFpEF患者的静态网络拓扑特征显著降低了局部网络效率；左侧海马旁回、左侧扣带回和右侧岛回的连接强度和信息处理效率降低，左侧丘脑、右侧梭状回和右侧楔前叶区的连接强度和信息处理效率提高。(2) HFpEF患者的动态网络拓扑特征显示关键节点和脑亚区（如额上回、左杏仁核和左梭状回）的变异性降低，特定区域（如右岛回、右中央后回和右颞回）的变异性代偿性增加。(3) HFpEF时，梭状回、扣带回、颞上回、楔前叶、海马旁回、岛回、杏仁核等区域的静态和动态功能脑网络拓扑特性与心脏结构和功能指标LVDd、LVMI、E/ E’比值显著相关。结论HFpEF患者心脏结构和功能的改变可能通过神经血管耦合机制影响特定脑网络的动态活动。

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Reconfiguration of dynamic brain networks in heart failure with preserved ejection fraction: Linking neurovascular coupling and cardiac dysfunction

Purpose

This study aimed to investigate the alterations in static and dynamic network topology properties in patients with heart failure with preserved ejection fraction (HFpEF).

Methods

Functional magnetic resonance imaging (fMRI) was obtained from 41 patients with HFpEF and 39 healthy individuals. The topology properties of static and dynamic functional brain networks were examined using graph theory methodologies, and the correlation between abnormal brain network characteristics and clinical features was assessed.

Results

(1) Static network topology properties exhibited significantly decreased local network efficiency among patients with HFpEF. The connectivity strength and information processing efficiency were diminished in the left parahippocampal gyrus, left cingulate gyrus, and right insular gyrus brain regions, and improved in the left thalamus, right fusiform gyrus, and right precuneus regions. (2) Dynamic network topology properties of patients with HFpEF showed decreased variability in critical nodes and brain subregions (e.g., the superior frontal gyrus, left amygdala, and left fusiform gyrus) and compensatory increases in the variability of specific regions (e.g., right insular gyrus, right postcentral gyrus, and right temporal gyrus). (3) In HFpEF, the static and dynamic functional brain network topology properties of the fusiform gyrus, cingulate gyrus, superior temporal gyrus, precuneus, parahippocampal gyrus, insular gyrus, and amygdala regions were significantly correlated with cardiac structural and functional indices, such as LVDd, LVMI, and E/e′ ratio.

Conclusion

Alterations in cardiac structure and function in HFpEF may affect the dynamic activity of specific brain networks through neurovascular coupling mechanisms.

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.