衰老大脑中的翻译交通堵塞

IF 45.8 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-07-31 DOI:10.1126/science.adz4995

Olivier Dionne, Benoit Laurent

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引用次数: 0

摘要

衰老是由几个并发的生物过程驱动的，这些过程可以总结为衰老标志的核心变化子集(1)。这些特征几乎涵盖了细胞生理学的所有方面，并且已知在进化上是保守的。蛋白质稳态（proteostasis）确保蛋白质在不再需要时被正确地合成、折叠和降解。蛋白质平衡的破坏是正常衰老的一个关键特征，通常与衰老的其他特征一起发生，包括基因组不稳定、线粒体功能障碍和表观遗传改变(2)。尽管如此，蛋白质平衡受损和其他衰老特征之间的明确分子联系尚未建立。在本期的第478页，Di Fraia等人(3)报道了一项对鳉鱼（Nothobranchius furzeri）大脑衰老的全面生化调查，发现一组必需蛋白质的产生被破坏是蛋白质平衡受损与其他衰老标志之间的联系。

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Translational traffic jam in aging brains

Aging is driven by several concurrent biological processes, which can be summarized in a subset of core alterations referred to as the hallmarks of aging (1). These hallmarks encompass almost all aspects of cellular physiology and are known to be evolutionarily well conserved. Protein homeostasis (proteostasis) ensures that proteins are correctly made, folded, and degraded when no longer needed. Disruption in proteostasis is a key feature of normal aging and often occurs alongside other hallmarks of aging, including genome instability, mitochondrial dysfunctions, and epigenetic alterations (2). Nonetheless, a definitive molecular link between impaired proteostasis and other aging hallmarks has yet to be established. On page 478 of this issue, Di Fraia et al. (3) report a comprehensive biochemical investigation of brain aging in the killifish (Nothobranchius furzeri) that identifies disrupted production of a group of essential proteins as a link between impaired proteostasis and other hallmarks of aging.

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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