肺癌中的氧化应激防御模块:分子途径和治疗方法。

IF 6.6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Eunsun Lee, Jeong Hee Hong
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引用次数: 0

摘要

调节氧化应激是治疗癌症的有效策略。调节不希望的氧化还原平衡对抗癌症的治疗策略包括增强氧化成分,降低抗氧化系统的作用,以及辐射和氧化还原调节药物的联合应用。对氧化还原调控的精确理解是治疗不同类型癌症的必要条件。本文就肺癌的氧化还原调控和氧化应激防御系统作一综述。因此,我们根据PubMed和scopus检索的文献,重点研究了几种酶促抗氧化成分,如超氧化物歧化酶、过氧化氢酶、血红素加氧酶-1、过氧化物还蛋白、谷胱甘肽还蛋白、硫氧还蛋白、硫氧还蛋白还原酶、谷胱甘肽过氧化物酶,以及抗氧化成分,包括谷胱甘肽、核因子红系2相关因子2,8 -氧-7,8-二氢-2′-脱氧鸟苷和线粒体柠檬酸载体SLC25A1。了解肺癌的氧化应激防御系统将有助于开发和扩展治疗策略,如药物开发、药物设计和先进的给药平台。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxidative Stress Defense Module in Lung Cancers: Molecular Pathways and Therapeutic Approaches.

The regulation of oxidative stress is an effective strategy for treating cancers. Therapeutic strategies for modulating an undesirable redox balance against cancers have included the enhancement of oxidative components, reducing the action of antioxidant systems, and the combined application of radiation and redox-modulating drugs. A precise understanding of redox regulation is required to treat different kinds of cancer. This review focuses on the redox regulation and oxidative stress defense systems of lung cancers. Thus, we highlighted several enzymatic antioxidant components, such as superoxide dismutase, catalase, heme oxygenase-1, peroxiredoxin, glutaredoxin, thioredoxin, thioredoxin reductase, glutathione peroxidase, and antioxidant components, including glutathione, nuclear factor erythroid 2-related factor 2, 8-oxo-7,8-dihydro-2'-deoxyguanosine, and mitochondrial citrate carrier SLC25A1, based on PubMed and Scopus-indexed literature. Understanding the oxidative stress defense system in lung cancer would be beneficial for developing and expanding therapeutic strategies, such as drug development, drug design, and advanced delivery platforms.

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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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