{"title":"炎症会使老化的肌肉干细胞生锈。","authors":"Ohanes Ashekyan, Michael A. Rudnicki","doi":"10.1038/s43587-025-00937-8","DOIUrl":null,"url":null,"abstract":"Skeletal muscle stem cells (MuSCs) are responsible for muscle repair and regeneration. Aging is associated with a decline in the number and function of MuSCs, a phenomenon that has been attributed to MuSC-intrinsic and MuSC-extrinsic factors. However, the relationship between these factors is yet to be fully defined. Here, Blanc and colleagues show that inflammation promotes epigenetic silencing in MuSCs via the KMT5A–H4K20me1 axis, which results in ferroptosis (a form of iron-dependent cell death).","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 8","pages":"1380-1382"},"PeriodicalIF":19.4000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Inflammation sends old muscle stem cells into a rusty meltdown\",\"authors\":\"Ohanes Ashekyan, Michael A. Rudnicki\",\"doi\":\"10.1038/s43587-025-00937-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Skeletal muscle stem cells (MuSCs) are responsible for muscle repair and regeneration. Aging is associated with a decline in the number and function of MuSCs, a phenomenon that has been attributed to MuSC-intrinsic and MuSC-extrinsic factors. However, the relationship between these factors is yet to be fully defined. Here, Blanc and colleagues show that inflammation promotes epigenetic silencing in MuSCs via the KMT5A–H4K20me1 axis, which results in ferroptosis (a form of iron-dependent cell death).\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":\"5 8\",\"pages\":\"1380-1382\"},\"PeriodicalIF\":19.4000,\"publicationDate\":\"2025-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-025-00937-8\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-025-00937-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Inflammation sends old muscle stem cells into a rusty meltdown
Skeletal muscle stem cells (MuSCs) are responsible for muscle repair and regeneration. Aging is associated with a decline in the number and function of MuSCs, a phenomenon that has been attributed to MuSC-intrinsic and MuSC-extrinsic factors. However, the relationship between these factors is yet to be fully defined. Here, Blanc and colleagues show that inflammation promotes epigenetic silencing in MuSCs via the KMT5A–H4K20me1 axis, which results in ferroptosis (a form of iron-dependent cell death).
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