Madison P. Cooper , Lisa M. Weatherly , Ewa Lukomska , Laurel G. Jackson , Stacey E. Anderson
{"title":"局部应用磺酸,全氟丁烷磺酸(PFBS)和全氟戊烷磺酸(PFPeS)对小鼠模型的全身毒性。","authors":"Madison P. Cooper , Lisa M. Weatherly , Ewa Lukomska , Laurel G. Jackson , Stacey E. Anderson","doi":"10.1016/j.taap.2025.117487","DOIUrl":null,"url":null,"abstract":"<div><div><em>Per</em>- and polyfluoroalkyl substances (PFAS) are a large group of synthetic surfactants incorporated into products for their chemical and physical properties. Studies have associated PFAS with adverse health effects. Although there is a high potential for dermal exposure, toxicity studies related to this route of exposure are lacking. The present study evaluated the systemic toxicity following a sub-chronic 28-day dermal exposure to perfluorobutane sulfonic acid (PFBS) (1.25–5 %) or perfluoropentane sulfonic acid (PFPeS) (1.25–5 %) in a murine model. Elevated levels of both PFAS were detected in the serum and urine, suggesting that absorption occurs through the skin. Additionally, both PFAS induced significantly increased relative liver weight, altered serum chemistries, altered skin and liver histopathology, and significantly decreased relative spleen weight (PFPeS only). Gene expression changes were observed in the liver and skin for genes involved in fatty acid metabolism, inflammation, and skin integrity. In general, the PFPeS-induced changes in the endpoints examined were observed more frequently compared to PFBS, supporting the concept that longer-chain PFAS are more toxic. These findings support PFAS absorption through the skin, leading to liver damage and systemic toxicity.</div></div>","PeriodicalId":23174,"journal":{"name":"Toxicology and applied pharmacology","volume":"503 ","pages":"Article 117487"},"PeriodicalIF":3.4000,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Systemic toxicity induced by topical application of the sulfonic acids, perfluorobutane sulfonic acid (PFBS) and perfluoropentane sulfonic acid (PFPeS), in a murine model\",\"authors\":\"Madison P. Cooper , Lisa M. Weatherly , Ewa Lukomska , Laurel G. Jackson , Stacey E. Anderson\",\"doi\":\"10.1016/j.taap.2025.117487\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div><em>Per</em>- and polyfluoroalkyl substances (PFAS) are a large group of synthetic surfactants incorporated into products for their chemical and physical properties. Studies have associated PFAS with adverse health effects. Although there is a high potential for dermal exposure, toxicity studies related to this route of exposure are lacking. The present study evaluated the systemic toxicity following a sub-chronic 28-day dermal exposure to perfluorobutane sulfonic acid (PFBS) (1.25–5 %) or perfluoropentane sulfonic acid (PFPeS) (1.25–5 %) in a murine model. Elevated levels of both PFAS were detected in the serum and urine, suggesting that absorption occurs through the skin. Additionally, both PFAS induced significantly increased relative liver weight, altered serum chemistries, altered skin and liver histopathology, and significantly decreased relative spleen weight (PFPeS only). Gene expression changes were observed in the liver and skin for genes involved in fatty acid metabolism, inflammation, and skin integrity. In general, the PFPeS-induced changes in the endpoints examined were observed more frequently compared to PFBS, supporting the concept that longer-chain PFAS are more toxic. These findings support PFAS absorption through the skin, leading to liver damage and systemic toxicity.</div></div>\",\"PeriodicalId\":23174,\"journal\":{\"name\":\"Toxicology and applied pharmacology\",\"volume\":\"503 \",\"pages\":\"Article 117487\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-07-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxicology and applied pharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0041008X25002637\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicology and applied pharmacology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0041008X25002637","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Systemic toxicity induced by topical application of the sulfonic acids, perfluorobutane sulfonic acid (PFBS) and perfluoropentane sulfonic acid (PFPeS), in a murine model
Per- and polyfluoroalkyl substances (PFAS) are a large group of synthetic surfactants incorporated into products for their chemical and physical properties. Studies have associated PFAS with adverse health effects. Although there is a high potential for dermal exposure, toxicity studies related to this route of exposure are lacking. The present study evaluated the systemic toxicity following a sub-chronic 28-day dermal exposure to perfluorobutane sulfonic acid (PFBS) (1.25–5 %) or perfluoropentane sulfonic acid (PFPeS) (1.25–5 %) in a murine model. Elevated levels of both PFAS were detected in the serum and urine, suggesting that absorption occurs through the skin. Additionally, both PFAS induced significantly increased relative liver weight, altered serum chemistries, altered skin and liver histopathology, and significantly decreased relative spleen weight (PFPeS only). Gene expression changes were observed in the liver and skin for genes involved in fatty acid metabolism, inflammation, and skin integrity. In general, the PFPeS-induced changes in the endpoints examined were observed more frequently compared to PFBS, supporting the concept that longer-chain PFAS are more toxic. These findings support PFAS absorption through the skin, leading to liver damage and systemic toxicity.
期刊介绍:
Toxicology and Applied Pharmacology publishes original scientific research of relevance to animals or humans pertaining to the action of chemicals, drugs, or chemically-defined natural products.
Regular articles address mechanistic approaches to physiological, pharmacologic, biochemical, cellular, or molecular understanding of toxicologic/pathologic lesions and to methods used to describe these responses. Safety Science articles address outstanding state-of-the-art preclinical and human translational characterization of drug and chemical safety employing cutting-edge science. Highly significant Regulatory Safety Science articles will also be considered in this category. Papers concerned with alternatives to the use of experimental animals are encouraged.
Short articles report on high impact studies of broad interest to readers of TAAP that would benefit from rapid publication. These articles should contain no more than a combined total of four figures and tables. Authors should include in their cover letter the justification for consideration of their manuscript as a short article.