辅酶Q10作为药物使用障碍的辅助治疗:临床前综述。

IF 1.1 4区 医学 Q3 SUBSTANCE ABUSE
Razieh Adabi, Alireza Masoudi, Raheleh Rafaiee, Fahimeh Mohseni
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引用次数: 0

摘要

物质使用障碍(sud)是一种慢性、复发性疾病,其特征是显著的神经生物学和行为中断。新出现的证据强调了氧化应激、线粒体功能障碍和神经炎症在药物滥用病理生理中的关键作用。辅酶Q10 (CoQ10)是一种线粒体辅助因子,具有有效的抗氧化和抗炎特性,作为一种潜在的辅助疗法,已引起人们的关注,用于管理物质相关的神经毒性。本文综述了辅酶q10在减轻物质滥用引起的氧化损伤和神经炎症中的机制作用,强调了其恢复线粒体功能和支持神经元健康的能力。临床前研究表明,补充辅酶q10可以减少细胞凋亡,保护神经递质系统,并改善可卡因、酒精、尼古丁和阿片类药物成瘾模型的行为结果。临床证据虽然有限,但表明辅酶q10在氧化应激相关疾病中的安全性和治疗潜力,加强了其与成瘾的相关性。尽管有这些有希望的发现,但诸如低生物利用度和缺乏针对sud的临床试验等挑战仍然是重大障碍。这一综述强调需要进一步研究优化辅酶q10的配方,给药策略和临床应用在治疗sud。将辅酶q10整合到多学科方法中可以提高我们解决sud复杂神经生物学挑战的能力,并改善长期恢复结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Coenzyme Q10 as an adjunctive treatment for substance use disorders: a preclinical review.

Substance use disorders (SUDs) are chronic, relapsing conditions characterized by significant neurobiological and behavioral disruptions. Emerging evidence highlights the critical roles of oxidative stress, mitochondrial dysfunction, and neuroinflammation in the pathophysiology of drug misuse. Coenzyme Q10 (CoQ10), a mitochondrial cofactor with potent antioxidant and anti-inflammatory properties, has gained attention as a potential adjunctive therapy for managing substance-related neurotoxicity. This review explores the mechanistic role of CoQ10 in mitigating the oxidative damage and neuroinflammation induced by substances misuse, emphasizing its ability to restore mitochondrial function and support neuronal health. Preclinical studies demonstrate that CoQ10 supplementation reduces apoptosis, preserves neurotransmitter systems, and improves behavioral outcomes in models of cocaine, alcohol, nicotine, and opioid addiction. Clinical evidence, though limited, suggests CoQ10's safety and therapeutic potential in oxidative stress-related conditions, reinforcing its relevance to addiction. Despite these promising findings, challenges such as low bioavailability and the lack of SUD-specific clinical trials remain significant barriers. This review underscores the need for further research to optimize CoQ10's formulation, dosing strategies, and clinical applications in the treatment of SUDs. Integrating CoQ10 into multidisciplinary approaches could advance our ability to address the complex neurobiological challenges of SUDs and improve long-term recovery outcomes.

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来源期刊
CiteScore
4.30
自引率
4.30%
发文量
69
期刊介绍: The Journal of Addictive Diseases is an essential, comprehensive resource covering the full range of addictions for today"s addiction professional. This in-depth, practical journal helps you stay on top of the vital issues and the clinical skills necessary to ensure effective practice. The latest research, treatments, and public policy issues in addiction medicine are presented in a fully integrated, multi-specialty perspective. Top researchers and respected leaders in addiction issues share their knowledge and insights to keep you up-to-date on the most important research and practical applications.
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